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TSPAN4 tetraspanin 4 [ Homo sapiens (human) ]

Gene ID: 7106, updated on 9-Feb-2020

Summary

Official Symbol
TSPAN4provided by HGNC
Official Full Name
tetraspanin 4provided by HGNC
Primary source
HGNC:HGNC:11859
See related
Ensembl:ENSG00000214063 MIM:602644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAG2; NAG-2; TM4SF7; TSPAN-4; TETRASPAN
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 26.0), spleen (RPKM 24.1) and 25 other tissues See more
Orthologs

Genomic context

See TSPAN4 in Genome Data Viewer
Location:
11p15.5
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (842824..867116)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (842824..867116)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD151 molecule (Raph blood group) Neighboring gene RNA polymerase II subunit L Neighboring gene chitinase domain containing 1 Neighboring gene adaptor related protein complex 2 subunit alpha 2 Neighboring gene RNA, U6 small nuclear 1025, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of TSPAN4 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of tetraspanin 4 (TSPAN4) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
focal adhesion HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tetraspanin-4
Names
novel antigen 2
tetraspan TM4SF
transmembrane 4 superfamily member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025234.1NP_001020405.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001020405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    AW204812, BC000389, BM555783, BM755435, BQ679002
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000380554.1, ENST00000397406.5
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  2. NM_001025235.1NP_001020406.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001020406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    AL543667, AW204812, BC000389, BM555783, BM755435
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  3. NM_001025236.1NP_001020407.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001020407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    AL543667, AW204812, BC000389, BG752017, BM555783, BM755435
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000380555.1, ENST00000397408.5
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  4. NM_001025237.1NP_001020408.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001020408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    AW204812, BC000389, BI820547, BM555783, BM755435
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000380553.1, ENST00000397404.5
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  5. NM_001025238.2NP_001020409.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001020409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    BC000389, BM555783, BM755435
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000380558.2, ENST00000397411.6
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  6. NM_001025239.1NP_001020410.1  tetraspanin-4 isoform b

    See identical proteins and their annotated locations for NP_001020410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AW204812, BC000389, BM555783, BM755435
    Consensus CDS
    CCDS41589.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A8MVV6
    Related
    ENSP00000380551.1, ENST00000397396.5
    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:1166
    Tetraspannin; Tetraspanin family
  7. NM_003271.5NP_003262.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_003262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same isoform (a).
    Source sequence(s)
    BC000389, BM555783, BM755435
    Consensus CDS
    CCDS7721.1
    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000380552.2, ENST00000397397.7
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    842824..867116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253104.1XP_005253161.1  tetraspanin-4 isoform X4

    See identical proteins and their annotated locations for XP_005253161.1

    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:33166
    Tetraspannin; Tetraspanin family
  2. XM_011520338.1XP_011518640.1  tetraspanin-4 isoform X3

    See identical proteins and their annotated locations for XP_011518640.1

    UniProtKB/TrEMBL
    A8MVV6
    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:1166
    Tetraspannin; Tetraspanin family
  3. XM_011520341.2XP_011518643.1  tetraspanin-4 isoform X3

    See identical proteins and their annotated locations for XP_011518643.1

    UniProtKB/TrEMBL
    A8MVV6
    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:1166
    Tetraspannin; Tetraspanin family
  4. XM_011520336.1XP_011518638.1  tetraspanin-4 isoform X1

    Conserved Domains (2) summary
    cd03165
    Location:136233
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:63261
    Tetraspannin; Tetraspanin family
  5. XM_011520339.2XP_011518641.1  tetraspanin-4 isoform X4

    See identical proteins and their annotated locations for XP_011518641.1

    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:33166
    Tetraspannin; Tetraspanin family
  6. XM_011520337.2XP_011518639.1  tetraspanin-4 isoform X3

    See identical proteins and their annotated locations for XP_011518639.1

    UniProtKB/TrEMBL
    A8MVV6
    Related
    ENSP00000431943.1, ENST00000525201.5
    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:1166
    Tetraspannin; Tetraspanin family
  7. XM_005253102.1XP_005253159.1  tetraspanin-4 isoform X2

    See identical proteins and their annotated locations for XP_005253159.1

    UniProtKB/Swiss-Prot
    O14817
    UniProtKB/TrEMBL
    A0A024RCE1
    Related
    ENSP00000386513.2, ENST00000409543.6
    Conserved Domains (1) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  8. XM_011520340.2XP_011518642.1  tetraspanin-4 isoform X3

    See identical proteins and their annotated locations for XP_011518642.1

    UniProtKB/TrEMBL
    A8MVV6
    Conserved Domains (2) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:1166
    Tetraspannin; Tetraspanin family
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