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Tspan4 tetraspanin 4 [ Mus musculus (house mouse) ]

Gene ID: 64540, updated on 25-Dec-2022

Summary

Official Symbol
Tspan4provided by MGI
Official Full Name
tetraspanin 4provided by MGI
Primary source
MGI:MGI:1928097
See related
Ensembl:ENSMUSG00000025511 AllianceGenome:MGI:1928097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAG-2; Tm4sf7; Tspan-4; D130042I01Rik
Summary
Predicted to enable antigen binding activity and integrin binding activity. Predicted to be involved in protein-containing complex assembly. Predicted to be located in plasma membrane and vesicle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; jaw; rib cage; urinary system; and viscerocranium. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 100.6), adrenal adult (RPKM 68.1) and 27 other tissues See more
Orthologs
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Genomic context

See Tspan4 in Genome Data Viewer
Location:
7; 7 F5
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141055149..141073340)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141475236..141493427)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10575 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene chitinase domain containing 1 Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC102386

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in migrasome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tetraspanin-4
Names
novel antigen 2
tetraspan TM4SF
transmembrane 4 superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252588.2NP_001239517.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_001239517.1

    Status: VALIDATED

    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22018.1
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    A0A6P5Q064, A0A8C6G4Z2, Q4FJW7
    Related
    ENSMUSP00000113085.2, ENSMUST00000117634.2
    Conserved Domains (2) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9226
    Tetraspannin; Tetraspanin family
  2. NM_001403355.1NP_001390284.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    A0A6P5Q064, A0A8C6G4Z2, Q4FJW7
  3. NM_001403356.1NP_001390285.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    A0A6P5Q064, A0A8C6G4Z2, Q4FJW7
  4. NM_001403357.1NP_001390286.1  tetraspanin-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    A0A6P5Q064, A0A8C6G4Z2, Q4FJW7
  5. NM_001403358.1NP_001390287.1  tetraspanin-4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/TrEMBL
    A0A668KLD1, A0A6P5PT62
  6. NM_053082.4NP_444312.1  tetraspanin-4 isoform a

    See identical proteins and their annotated locations for NP_444312.1

    Status: VALIDATED

    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22018.1
    UniProtKB/Swiss-Prot
    Q9DCK3
    UniProtKB/TrEMBL
    A0A6P5Q064, A0A8C6G4Z2, Q4FJW7
    Related
    ENSMUSP00000026585.8, ENSMUST00000026585.14
    Conserved Domains (2) summary
    cd03165
    Location:105202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9226
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141055149..141073340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153326.1XP_036009219.1  tetraspanin-4 isoform X3

    Conserved Domains (1) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  2. XM_006536224.5XP_006536287.1  tetraspanin-4 isoform X2

    See identical proteins and their annotated locations for XP_006536287.1

    Conserved Domains (2) summary
    cd03165
    Location:138235
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:42259
    Tetraspannin; Tetraspanin family
  3. XM_036153327.1XP_036009220.1  tetraspanin-4 isoform X3

    Conserved Domains (1) summary
    cd03165
    Location:41138
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  4. XM_030242865.2XP_030098725.1  tetraspanin-4 isoform X1

    Related
    ENSMUSP00000159235.2, ENSMUST00000239217.2
    Conserved Domains (2) summary
    cd03165
    Location:200297
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:104321
    Tetraspannin; Tetraspanin family