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TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 7073, updated on 8-Jan-2019

Summary

Official Symbol
TIAL1provided by HGNC
Official Full Name
TIA1 cytotoxic granule associated RNA binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:11804
See related
Ensembl:ENSG00000151923 MIM:603413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCBP; TIAR
Summary
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See TIAL1 in Genome Data Viewer
Location:
10q26.11
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (119573465..119598841, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356541, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene microRNA 4681 Neighboring gene regulator of G protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
    FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
stem cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nucleolysin TIAR
Names
T-cluster binding protein
TIA-1-related nucleolysin
TIA1 related
aging-associated gene 7 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029240.1 RefSeqGene

    Range
    5001..28565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033925.1NP_001029097.1  nucleolysin TIAR isoform 2

    See identical proteins and their annotated locations for NP_001029097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
    Source sequence(s)
    AA972022, AC012468, AK125264, BC030025, M96954
    Consensus CDS
    CCDS31295.1
    UniProtKB/Swiss-Prot
    Q01085
    UniProtKB/TrEMBL
    Q49AS9
    Related
    ENSP00000358089.2, ENST00000369093.6
    Conserved Domains (3) summary
    cd12616
    Location:10107
    RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
    cd12617
    Location:113192
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:222294
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
  2. NM_001323964.1NP_001310893.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
    Source sequence(s)
    AC012468, BC030025
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001323965.1NP_001310894.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_001323967.1NP_001310896.1  nucleolysin TIAR isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
    Source sequence(s)
    AC012468
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. NM_001323968.1NP_001310897.1  nucleolysin TIAR isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012468
  6. NM_001323969.1NP_001310898.1  nucleolysin TIAR isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC012468
    Conserved Domains (3) summary
    cd12617
    Location:57136
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:166238
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:151
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_001323970.1NP_001310899.1  nucleolysin TIAR isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012468, BC128140
    Conserved Domains (3) summary
    cd12617
    Location:74153
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:183255
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:1968
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. NM_003252.3NP_003243.1  nucleolysin TIAR isoform 1

    See identical proteins and their annotated locations for NP_003243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AA972022, AC012468, AK125264, AL833106, BC030025
    Consensus CDS
    CCDS7613.1
    UniProtKB/Swiss-Prot
    Q01085
    UniProtKB/TrEMBL
    Q49AS9
    Related
    ENSP00000394902.2, ENST00000436547.6
    Conserved Domains (3) summary
    cd12616
    Location:1090
    RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
    cd12617
    Location:96175
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:205277
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins

RNA

  1. NR_136661.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468, AL833106, BC030025
  2. NR_136662.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468
  3. NR_136663.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012468, D64015

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    119573465..119598841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448151.1XP_024303919.1  nucleolysin TIAR isoform X1

    Conserved Domains (3) summary
    cd12617
    Location:74153
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:183255
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:1968
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_945808.2 RNA Sequence

  2. XR_001747195.2 RNA Sequence

  3. XR_001747194.2 RNA Sequence

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