U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 21843, updated on 9-May-2024

Summary

Official Symbol
Tial1provided by MGI
Official Full Name
Tia1 cytotoxic granule-associated RNA binding protein-like 1provided by MGI
Primary source
MGI:MGI:107913
See related
Ensembl:ENSMUSG00000030846 AllianceGenome:MGI:107913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIAR; mTIAR; 5330433G13Rik
Summary
Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within germ cell development; positive regulation of cell population proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; and trunk. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 23.5), CNS E14 (RPKM 22.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tial1 in Genome Data Viewer
Location:
7 F3; 7 70.2 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128041496..128063450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128439772..128461726, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135535641-135535842 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135542158-135542359 Neighboring gene STARR-seq mESC enhancer starr_20202 Neighboring gene predicted gene, 32765 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135605111-135605220 Neighboring gene predicted gene, 32816 Neighboring gene STARR-seq mESC enhancer starr_20203 Neighboring gene predicted gene, 57509

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleolysin TIAR
Names
TIA-1-related protein
Tial1 cytotoxic granule-associated RNA binding protein-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347640.1NP_001334569.1  nucleolysin TIAR isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC130474
    Consensus CDS
    CCDS85429.1
    UniProtKB/TrEMBL
    Q921W2
    Related
    ENSMUSP00000033135.8, ENSMUST00000033135.9
    Conserved Domains (3) summary
    cd12620
    Location:205277
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:1090
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:96175
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
  2. NM_001347641.1NP_001334570.1  nucleolysin TIAR isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC130474
    Consensus CDS
    CCDS85428.1
    UniProtKB/TrEMBL
    D3Z3Y4, Q6NVC2
    Related
    ENSMUSP00000101835.3, ENSMUST00000106228.8
    Conserved Domains (3) summary
    cd12620
    Location:166238
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:57136
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:151
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_009383.2NP_033409.1  nucleolysin TIAR isoform 1

    See identical proteins and their annotated locations for NP_033409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC130474, AK012085
    Consensus CDS
    CCDS21897.1
    UniProtKB/Swiss-Prot
    P70318
    UniProtKB/TrEMBL
    Q545C1
    Related
    ENSMUSP00000101833.3, ENSMUST00000106226.9
    Conserved Domains (3) summary
    cd12620
    Location:222294
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12616
    Location:10107
    RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:113192
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    128041496..128063450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507571.4XP_006507634.1  nucleolysin TIAR isoform X1

    See identical proteins and their annotated locations for XP_006507634.1

    Conserved Domains (3) summary
    cd12620
    Location:183255
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cd12617
    Location:74153
    RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:1968
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_036152887.1XP_036008780.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_030242350.1XP_030098210.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_030242352.1XP_030098212.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_036152890.1XP_036008783.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_036152888.1XP_036008781.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_030242349.2XP_030098209.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Related
    ENSMUSP00000145933.2, ENSMUST00000141126.8
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_030242346.2XP_030098206.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_030242353.2XP_030098213.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. XM_030242351.2XP_030098211.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  11. XM_017322108.3XP_017177597.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_030242348.2XP_030098208.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_030242354.2XP_030098214.1  nucleolysin TIAR isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPD3
    Conserved Domains (2) summary
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_004934057.1 RNA Sequence

  2. XR_378231.4 RNA Sequence

  3. XR_378230.4 RNA Sequence

  4. XR_004934056.1 RNA Sequence