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THBS2 thrombospondin 2 [ Homo sapiens (human) ]

Gene ID: 7058, updated on 23-Nov-2021

Summary

Official Symbol
THBS2provided by HGNC
Official Full Name
thrombospondin 2provided by HGNC
Primary source
HGNC:HGNC:11786
See related
Ensembl:ENSG00000186340 MIM:188061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSP2
Summary
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 49.1), endometrium (RPKM 31.3) and 18 other tissues See more
Orthologs
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Genomic context

See THBS2 in Genome Data Viewer
Location:
6q27
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (169215785..169253846, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (169615880..169653941, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1615 Neighboring gene long intergenic non-protein coding RNA 2544 Neighboring gene uncharacterized LOC101929523 Neighboring gene vesicle trafficking 1 pseudogene 1 Neighboring gene uncharacterized LOC105378148

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intervertebral disc disorder
MedGen: C0158252 OMIM: 603932 GeneReviews: Not available
Compare labs
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022911.1 RefSeqGene

    Range
    4929..43263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381939.1NP_001368868.1  thrombospondin-2 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    BX322234
    Related
    ENSP00000504416.1, ENST00000676628.1
    Conserved Domains (11) summary
    smart00209
    Location:440492
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:20215
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:789826
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:731765
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:635670
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:320374
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:789826
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:385430
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:9161113
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:594633
    EGF_3; EGF domain
    NF033845
    Location:707935
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  2. NM_001381940.1NP_001368869.1  thrombospondin-2 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    BX322234
    Related
    ENST00000677398.1
    Conserved Domains (5) summary
    smart00209
    Location:497549
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:20215
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:320374
    VWC; von Willebrand factor type C domain
    pfam00090
    Location:385430
    TSP_1; Thrombospondin type 1 domain
    pfam12947
    Location:652691
    EGF_3; EGF domain
  3. NM_001381941.1NP_001368870.1  thrombospondin-2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    BX322234
    Conserved Domains (1) summary
    smart00210
    Location:20215
    TSPN; Thrombospondin N-terminal -like domains
  4. NM_001381942.1NP_001368871.1  thrombospondin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    BX322234
    Conserved Domains (11) summary
    smart00209
    Location:420472
    TSP1; Thrombospondin type 1 repeats
    sd00001
    Location:770807
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:712746
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:616651
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00093
    Location:243297
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:770807
    TSP_3; Thrombospondin type 3 repeat
    pfam00090
    Location:308353
    TSP_1; Thrombospondin type 1 domain
    pfam05735
    Location:8971094
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:575614
    EGF_3; EGF domain
    NF033845
    Location:688916
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22861
    Location:1138
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  5. NM_003247.5NP_003238.2  thrombospondin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003238.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BX322234
    Consensus CDS
    CCDS34574.1
    UniProtKB/Swiss-Prot
    P35442
    Related
    ENSP00000482784.1, ENST00000617924.6
    Conserved Domains (10) summary
    smart00209
    Location:497549
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:20215
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:847884
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:789823
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:693728
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:385430
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:320374
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:848884
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:9741171
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:652691
    EGF_3; EGF domain

RNA

  1. NR_167744.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BX322234
    Related
    ENST00000677429.1
  2. NR_167745.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BX322234

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    169215785..169253846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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