1YO8


Conserved Protein Domain Family
TSP3_1C

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sd00003: TSP3_1C 
Click on image for an interactive view with Cn3D
Calcium-binding Thrombospondin type 3 (TSP3) repeat; C-type motif 1C
TSP3 repeats of the vertebrate thrombospondin (TSP)-1,-2,-3,-4 and TSP-5/also known as COMP (cartilage oligomeric matrix protein), and related proteins. These short aspartate-rich repeats are a continuous series of calcium binding sites that can be divided into two sequence motifs: N-type and C-type. N-type and C-type motifs are distinguished by their sequence length, calcium ion binding, and their interactions with water molecules. C-type motifs are higher affinity binding sites compared to N-type motifs. The first TSP3 repeat 1C deviates from the canonical C-type calcium binding repeat in containing an insert relative to the other C-type repeats, however, the residues of the interrupted halves are positioned identically to C-type repeats without the insert.
Statistics
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PSSM-Id: 275367
View PSSM: sd00003
Aligned: 7 rows
Threshold Bit Score: 53.6559
Threshold Setting Gi: 167880510
Created: 22-Dec-2011
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
 
TSP3 repeat_1CC-type Ca
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:TSP3 repeat_1C [structural motif]
Evidence:
  • Comment: The TSP type 3 repeats are a continuous series of calcium binding sites that can be divided into two sequence motifs: N-type and C-type. TSP3 repeat 1C has a C-type motif.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30
                  ....*....|....*....|....*....|....*.
Feature 1         ###############       ##############
1YO8_A        146 EDSDLDGWPNLNLVCatnatyhCIKDNCPHLPNSGQ 181
gi 225479     691 EDTDLDGWPNENLVCvanatyhCKKDNCPNLPNSGQ 726
gi 167880510  293 KDSDSDGYPDEGLNCke---ptCTRDNCKVQPNSGQ 325
gi 86610893   481 IDSDLDGYPDAALPCte---qtCRKDNCRLTPNSGQ 513
gi 549133     699 EDSDLDGWPNNNLVCaanatyhCVKDNCPLLPNSGQ 734
gi 6978679    266 RDTDLDGFPDEKLRCse---rqCRKDNCVTVPNSGQ 298
gi 110816450  431 PDSDIDGYPDEPLPCmdn-dkhCRADNCANTPNSGQ 465

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