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Zc3h11a zinc finger CCCH type containing 11A [ Mus musculus (house mouse) ]

Gene ID: 70579, updated on 17-Aug-2024

Summary

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Official Symbol
Zc3h11aprovided by MGI
Official Full Name
zinc finger CCCH type containing 11Aprovided by MGI
Primary source
MGI:MGI:1917829
See related
Ensembl:ENSMUSG00000102976 AllianceGenome:MGI:1917829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zc3hh11a; Zc3hdc11a; mKIAA0663; 1110003F06Rik; 5730454B08Rik; G630041M05Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to act upstream of or within mRNA transport. Predicted to be part of transcription export complex. Orthologous to human ZC3H11A (zinc finger CCCH-type containing 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 42.5), bladder adult (RPKM 39.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 57.94 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133547600..133589137, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133619862..133661399, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene predicted gene, 23939 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene microRNA 6903

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes. Younis S, et al. Proc Natl Acad Sci U S A, 2023 Jun 6. PMID 37252988, Free PMC Article
  2. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.
    Title: The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.
  2. Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes.
    Title: Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0663

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 11A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276767.1 → NP_001263696.1  zinc finger CCCH domain-containing protein 11A

    See identical proteins and their annotated locations for NP_001263696.1

    Status: VALIDATED

    Source sequence(s)
    AC124338
    Consensus CDS
    CCDS15297.1
    UniProtKB/Swiss-Prot
    Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
    UniProtKB/TrEMBL
    Q3TIV2, Q3UL31
    Related
    ENSMUSP00000141255.2, ENSMUST00000191896.6
    Conserved Domains (1) summary
    pfam15663
    Location:1 → 110
    zf-CCCH_3; Zinc-finger containing family

  2. NM_001357228.1 → NP_001344157.1  zinc finger CCCH domain-containing protein 11A

    Status: VALIDATED

    Source sequence(s)
    AC124338
    Consensus CDS
    CCDS15297.1
    UniProtKB/Swiss-Prot
    Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
    UniProtKB/TrEMBL
    Q3TIV2, Q3UL31
    Conserved Domains (1) summary
    pfam15663
    Location:1 → 110
    zf-CCCH_3; Zinc-finger containing family

  3. NM_144530.6 → NP_653113.4  zinc finger CCCH domain-containing protein 11A

    See identical proteins and their annotated locations for NP_653113.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124338
    Consensus CDS
    CCDS15297.1
    UniProtKB/Swiss-Prot
    Q6NXW9, Q6NZF1, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6
    UniProtKB/TrEMBL
    Q3TIV2, Q3UL31
    Conserved Domains (1) summary
    pfam15663
    Location:1 → 110
    zf-CCCH_3; Zinc-finger containing family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133547600..133589137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZF1.1 GenPept UniProtKB/Swiss-Prot:Q6NZF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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