TGFBR3 transforming growth factor beta receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TGFBR3provided by HGNC
Official Full Name: transforming growth factor beta receptor 3provided by HGNC
Primary source: HGNC:HGNC:11774
See related: Ensembl:ENSG00000069702 MIM:600742
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BGCAN; betaglycan
Summary: This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in fat (RPKM 40.0), ovary (RPKM 37.4) and 23 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1p22.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (91680343..91906002, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (92145900..92371559, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsa_circ_0042666 regulated laryngeal squamous cell carcinoma cell proliferation and invasion by miR-223/TGFBR3 axis.
Title: Hsa_circ_0042666 inhibits proliferation and invasion via regulating miR-223/TGFBR3 axis in laryngeal squamous cell carcinoma.
findings suggest a betaglycan-Wnt5a circuit represents an attractive vulnerability to ameliorate prostate cancer-induced osteogenesis
Title: Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis.
TGFBR3 is targeted by MiR-501 which binds to its 3'UTR. Pancreatic ductal adenocarcinoma (PDAC) cells presented with down-regulated TGFBR3 expression by MiR-501 through the TGF-beta signaling pathway.
Title: Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway.
A dormancy mechanism by which DTCs are induced into a dormant state through TGFbetaRIII-p38MAPK-pS249/pT252-RB signaling.
Title: Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.
Low TGFBR3 expression is associated with progression of lung cancer.
Title: Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3.
also observed that the promotion of epithelial-to-mesenchymal transition by miR-19a and miR-424 was mediated by the inhibition of TGFBR3
Title: miR-19a and miR-424 target TGFBR3 to promote epithelial-to-mesenchymal transition and migration of tongue squamous cell carcinoma cells.
Loss of TGFBR3 endows clear cell renal cell carcinoma cells with multiple metastatic abilities through TGF-beta-dependent and independent pathways.
Title: Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms.
We suggest that TGFBR3 protein expression is involved in up-regulated TGF-beta signaling in Marfan syndrome patients with a dominant negative FBN1 gene mutation.
Title: Betaglycan (TGFBR3) up-regulation correlates with increased TGF-β signaling in Marfan patient fibroblasts in vitro.
describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells
Title: TβRIII is induced by TCR signaling and downregulated in FoxP3<sup>+</sup> regulatory T cells.
TGF-beta type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.
Title: Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide association study of optic disc parameters. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpu	vpu	Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse HIV-1 Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-58228 (e-PCR)
- UniSTS:32527

G59838 (e-PCR)
- UniSTS:136987

D1S3573 (e-PCR)
- UniSTS:46638

SHGC-148101 (e-PCR)
- UniSTS:176192

RH68993 (e-PCR)
- UniSTS:59985

D1S3441 (e-PCR)
- UniSTS:74844

AL009304 (e-PCR)
- UniSTS:47206

D1S1588 (e-PCR), detects polymorphism
- UniSTS:39069

SHGC-30223 (e-PCR)
- UniSTS:76980

SHGC-75157 (e-PCR)
- UniSTS:3258

SHGC-75166 (e-PCR)
- UniSTS:28664

TGFBR3_3871 (e-PCR)
- UniSTS:462586

Homology

Homologs of the TGFBR3 gene: The TGFBR3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 313 organisms have orthologs with human gene TGFBR3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
SMAD binding	IMP Inferred from Mutant Phenotype more info	PubMed
activin binding	IEA Inferred from Electronic Annotation more info
coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glycosaminoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
glycosaminoglycan binding	TAS Traceable Author Statement more info	PubMed
heparin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transforming growth factor beta binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transforming growth factor beta binding	IPI Inferred from Physical Interaction more info	PubMed
transforming growth factor beta receptor activity, type III	IDA Inferred from Direct Assay more info	PubMed
transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
transforming growth factor beta-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transforming growth factor beta-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed
type II transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
type II transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
animal organ regeneration	IEA Inferred from Electronic Annotation more info
cardiac epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell migration	ISS Inferred from Sequence or Structural Similarity more info
definitive erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
definitive hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
epicardium-derived cardiac fibroblast cell development	ISS Inferred from Sequence or Structural Similarity more info
epithelial to mesenchymal transition	IBA Inferred from Biological aspect of Ancestor more info	PubMed
epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
heart trabecula formation	ISS Inferred from Sequence or Structural Similarity more info
heart trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
immune response	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
liver development	ISS Inferred from Sequence or Structural Similarity more info
muscular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cellular component movement	IDA Inferred from Direct Assay more info	PubMed
negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
pathway-restricted SMAD protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
NOT regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
NOT regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of protein binding	IEA Inferred from Electronic Annotation more info
regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to follicle-stimulating hormone	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to luteinizing hormone	IDA Inferred from Direct Assay more info	PubMed
response to prostaglandin E	IDA Inferred from Direct Assay more info	PubMed
secondary palate development	ISS Inferred from Sequence or Structural Similarity more info
transforming growth factor beta receptor complex assembly	IEA Inferred from Electronic Annotation more info
transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
vasculogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vasculogenesis involved in coronary vascular morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
ventricular cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
ventricular compact myocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell surface	ISS Inferred from Sequence or Structural Similarity more info
cytoplasm	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular matrix	IEA Inferred from Electronic Annotation more info
extracellular space	HDA more info	PubMed
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	TAS Traceable Author Statement more info	PubMed
inhibin-betaglycan-ActRII complex	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transforming growth factor beta receptor type 3

Names: TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; betaglycan proteoglycan; transforming growth factor beta receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027757.1 RefSeqGene

Range

5001..230660

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001195683.2 → NP_001182612.1 transforming growth factor beta receptor type 3 isoform b precursor

See identical proteins and their annotated locations for NP_001182612.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC099334, AI090023, AK225799, AK291345, BC136295, DA854401, DR002506

Consensus CDS

CCDS55614.1

UniProtKB/Swiss-Prot

Q03167

UniProtKB/TrEMBL

A0A0A8KWK3

Related

ENSP00000432638.1, ENST00000465892.6

Conserved Domains (2) summary

smart00241
Location:454 → 724

ZP; Zona pellucida (ZP) domain

pfam00100
Location:566 → 723

Zona_pellucida; Zona pellucida-like domain
NM_001195684.1 → NP_001182613.1 transforming growth factor beta receptor type 3 isoform b precursor

See identical proteins and their annotated locations for NP_001182613.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC099334, AI090023, AK225799, AK291345, BC136295, DA862176, DR002506

Consensus CDS

CCDS55614.1

UniProtKB/Swiss-Prot

Q03167

UniProtKB/TrEMBL

A0A0A8KWK3

Related

ENSP00000359426.2, ENST00000370399.6

Conserved Domains (2) summary

smart00241
Location:454 → 724

ZP; Zona pellucida (ZP) domain

pfam00100
Location:566 → 723

Zona_pellucida; Zona pellucida-like domain
NM_003243.5 → NP_003234.2 transforming growth factor beta receptor type 3 isoform a precursor

See identical proteins and their annotated locations for NP_003234.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC099334, AI090023, AK291345, BC136295, DA854401, DR002506

Consensus CDS

CCDS30770.1

UniProtKB/Swiss-Prot

Q03167

Related

ENSP00000212355.4, ENST00000212355.9

Conserved Domains (2) summary

smart00241
Location:455 → 725

ZP; Zona pellucida (ZP) domain

pfam00100
Location:567 → 724

Zona_pellucida; Zona pellucida-like domain

RNA

NR_036634.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC099334, AI090023, AK291345, BC136295, BC143869, DA854401, DR002506

Related

ENST00000533089.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p13 Primary Assembly

Range

91680343..91906002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006710867.2 → XP_006710930.1 transforming growth factor beta receptor type 3 isoform X1

See identical proteins and their annotated locations for XP_006710930.1

UniProtKB/Swiss-Prot

Q03167

Related

ENSP00000436127.1, ENST00000525962.5

Conserved Domains (2) summary

smart00241
Location:455 → 725

ZP; Zona pellucida (ZP) domain

pfam00100
Location:567 → 724

Zona_pellucida; Zona pellucida-like domain