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Tgfbr3 transforming growth factor, beta receptor III [ Mus musculus (house mouse) ]

Gene ID: 21814, updated on 5-Mar-2024

Summary

Official Symbol
Tgfbr3provided by MGI
Official Full Name
transforming growth factor, beta receptor IIIprovided by MGI
Primary source
MGI:MGI:104637
See related
Ensembl:ENSMUSG00000029287 AllianceGenome:MGI:104637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TBRIII; 1110036H20Rik
Summary
Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; heart; lower jaw; and ovary. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 38.6), bladder adult (RPKM 20.1) and 20 other tissues See more
Orthologs
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Genomic context

See Tgfbr3 in Genome Data Viewer
Location:
5 E5; 5 51.9 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107254433..107437495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107106567..107289629, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33474 Neighboring gene STARR-seq mESC enhancer starr_13883 Neighboring gene predicted gene, 42146 Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13887 Neighboring gene predicted gene, 22557 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:107786881-107787082 Neighboring gene STARR-positive B cell enhancer mm9_chr5:107788417-107788718 Neighboring gene bromodomain, testis-specific Neighboring gene STARR-seq mESC enhancer starr_13888 Neighboring gene predicted gene 17202 Neighboring gene high mobility group protein B1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transforming growth factor beta receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transforming growth factor beta receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity, type III ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel diameter maintenance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in coronary vasculature development TAS
Traceable Author Statement
more info
PubMed 
involved_in coronary vasculature morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epicardial cell to mesenchymal cell transition TAS
Traceable Author Statement
more info
PubMed 
involved_in epicardium-derived cardiac fibroblast cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to follicle-stimulating hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to luteinizing hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to prostaglandin E ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular compact myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visceral serous pericardium development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of inhibin-betaglycan-ActRII complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transforming growth factor beta receptor type 3
Names
TGF-beta receptor type 3
TGF-beta receptor type III
TGFR-3
betaglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011578.4NP_035708.2  transforming growth factor beta receptor type 3 precursor

    See identical proteins and their annotated locations for NP_035708.2

    Status: VALIDATED

    Source sequence(s)
    AC133897, AC166776
    Consensus CDS
    CCDS19499.1
    UniProtKB/Swiss-Prot
    O88393, Q6NS72
    UniProtKB/TrEMBL
    A0A0R4J097
    Related
    ENSMUSP00000031224.9, ENSMUST00000031224.15
    Conserved Domains (2) summary
    smart00241
    Location:454723
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:597722
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107254433..107437495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)