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TGM4 transglutaminase 4 [ Homo sapiens (human) ]

Gene ID: 7047, updated on 23-Nov-2023

Summary

Official Symbol
TGM4provided by HGNC
Official Full Name
transglutaminase 4provided by HGNC
Primary source
HGNC:HGNC:11780
See related
Ensembl:ENSG00000163810 MIM:600585; AllianceGenome:HGNC:11780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGP; hTGP
Summary
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Located in Golgi apparatus and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward prostate (RPKM 891.0) See more
Orthologs
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Genomic context

See TGM4 in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44874608..44914990)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44890333..44930718)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44916100..44956482)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14274 Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44975255-44976082 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981025-44981526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981527-44982026 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:45000471-45001670 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45016646-45017190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14276 Neighboring gene exosome component 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19773

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cyclosporin (CsA) treatment prevents gp120-dependent induction of apoptosis by blocking the activation of Ca(2+)-dependent effector elements such as transglutaminase (TG) proteins PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro; soluble CD4 can block the transglutaminase-catalyzed incorporation of the polyamine spermidine into HIV-1 gp41 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein-glutamine gamma-glutamyltransferase 4
Names
TG(P)
TGase P
TGase-4
fibrinoligase
prostate transglutaminase
prostate-specific transglutaminase
transglutaminase 4 (prostate)
transglutaminase P
NP_003232.2
XP_011532344.1
XP_054187531.1
XP_054203640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003241.4NP_003232.2  protein-glutamine gamma-glutamyltransferase 4

    See identical proteins and their annotated locations for NP_003232.2

    Status: VALIDATED

    Source sequence(s)
    AC098649, BC007003, BF678064, DA870110, L34840
    Consensus CDS
    CCDS2723.1
    UniProtKB/Swiss-Prot
    P49221, Q16707, Q96QN4
    UniProtKB/TrEMBL
    B2R7D1
    Related
    ENSP00000296125.4, ENST00000296125.9
    Conserved Domains (4) summary
    smart00460
    Location:263353
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:266353
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:9122
    Transglut_N; Transglutaminase family
    pfam00927
    Location:587684
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44874608..44914990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534042.3XP_011532344.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_011532344.1

    UniProtKB/TrEMBL
    A0A994J576, B2R7D1
    Related
    ENSP00000516167.1, ENST00000705784.1
    Conserved Domains (4) summary
    smart00460
    Location:308398
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:311398
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:54167
    Transglut_N; Transglutaminase family
    pfam00927
    Location:632729
    Transglut_C; Transglutaminase family, C-terminal ig like domain

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    399958..440340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331556.1XP_054187531.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

    UniProtKB/TrEMBL
    A0A994J576, B2R7D1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44890333..44930718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347665.1XP_054203640.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

    UniProtKB/TrEMBL
    A0A994J576, B2R7D1