Format

Send to:

Choose Destination

TGM4 transglutaminase 4 [ Homo sapiens (human) ]

Gene ID: 7047, updated on 11-Jun-2021

Summary

Official Symbol
TGM4provided by HGNC
Official Full Name
transglutaminase 4provided by HGNC
Primary source
HGNC:HGNC:11780
See related
Ensembl:ENSG00000163810 MIM:600585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGP; hTGP
Expression
Restricted expression toward prostate (RPKM 891.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TGM4 in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44874608..44914990)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44916100..44956482)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene exosome component 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cyclosporin (CsA) treatment prevents gp120-dependent induction of apoptosis by blocking the activation of Ca(2+)-dependent effector elements such as transglutaminase (TG) proteins PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro; soluble CD4 can block the transglutaminase-catalyzed incorporation of the polyamine spermidine into HIV-1 gp41 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-glutamine gamma-glutamyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein-glutamine gamma-glutamyltransferase 4
Names
TG(P)
TGase P
TGase-4
fibrinoligase
prostate transglutaminase
prostate-specific transglutaminase
transglutaminase 4 (prostate)
transglutaminase P
NP_003232.2
XP_011532344.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003241.4NP_003232.2  protein-glutamine gamma-glutamyltransferase 4

    See identical proteins and their annotated locations for NP_003232.2

    Status: VALIDATED

    Source sequence(s)
    AC098649, BC007003, BF678064, DA870110, L34840
    Consensus CDS
    CCDS2723.1
    UniProtKB/Swiss-Prot
    P49221
    Related
    ENSP00000296125.4, ENST00000296125.9
    Conserved Domains (4) summary
    smart00460
    Location:263353
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:266353
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:9122
    Transglut_N; Transglutaminase family
    pfam00927
    Location:587684
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44874608..44914990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534042.2XP_011532344.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_011532344.1

    Conserved Domains (4) summary
    smart00460
    Location:308398
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:311398
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:54167
    Transglut_N; Transglutaminase family
    pfam00927
    Location:632729
    Transglut_C; Transglutaminase family, C-terminal ig like domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p13 PATCHES

    Range
    399958..440340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center