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TCP1 t-complex 1 [ Homo sapiens (human) ]

Gene ID: 6950, updated on 17-Oct-2021

Summary

Official Symbol
TCP1provided by HGNC
Official Full Name
t-complex 1provided by HGNC
Primary source
HGNC:HGNC:11655
See related
Ensembl:ENSG00000120438 MIM:186980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in testis (RPKM 91.3), brain (RPKM 50.5) and 25 other tissues See more
Orthologs
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Genomic context

See TCP1 in Genome Data Viewer
Location:
6q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (159778498..159789602, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160199530..160210634, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene superoxide dismutase 2 Neighboring gene WT1 associated protein Neighboring gene SOD2 overlapping transcript 1 Neighboring gene acetyl-CoA acetyltransferase 2 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene small nucleolar RNA, H/ACA box 29 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene PARN like ribonuclease domain containing exonuclease 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify t-complex 1 (TCP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify t-complex 1 (TCP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify t-complex 1 (TCP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify t-complex 1 (TCP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vif vif HIV-1 Vif interacts with TCP1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to Cajal body HMP PubMed 
involved_in positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
involved_in positive regulation of telomerase RNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of macrophage apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in scaRNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toxin transport IEA
Inferred from Electronic Annotation
more info
 
involved_in translocation of peptides or proteins into host cell cytoplasm IEA
Inferred from Electronic Annotation
more info
 
involved_in tubulin complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericentriolar material IEA
Inferred from Electronic Annotation
more info
 
part_of zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit alpha
Names
T-complex protein 1, alpha subunit
t-complex 1 protein
tailless complex polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008897.2NP_001008897.1  T-complex protein 1 subunit alpha isoform b

    See identical proteins and their annotated locations for NP_001008897.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA810047, AL135914, BM697304, BM827784
    Consensus CDS
    CCDS43522.1
    UniProtKB/TrEMBL
    E7EQR6
    Related
    ENSP00000376008.2, ENST00000392168.6
    Conserved Domains (1) summary
    cl02777
    Location:1380
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  2. NM_030752.3NP_110379.2  T-complex protein 1 subunit alpha isoform a

    See identical proteins and their annotated locations for NP_110379.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA810047, BC000665, BM697304, BM827784
    Consensus CDS
    CCDS5269.1
    UniProtKB/Swiss-Prot
    P17987
    Related
    ENSP00000317334.7, ENST00000321394.12
    Conserved Domains (1) summary
    cd03335
    Location:9535
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    159778498..159789602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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