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Tcp1 t-complex protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21454, updated on 26-Sep-2022

Summary

Official Symbol
Tcp1provided by MGI
Official Full Name
t-complex protein 1provided by MGI
Primary source
MGI:MGI:98535
See related
Ensembl:ENSMUSG00000068039 AllianceGenome:MGI:98535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn
Summary
Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; toxin transport; and translocation of peptides or proteins into host cell cytoplasm. Located in several cellular components, including acrosomal vesicle; heterochromatin; and pericentriolar material. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including cerebral cortex; extraembryonic component; genitourinary system; humerus; and immune system. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 173.1), CNS E11.5 (RPKM 109.2) and 25 other tissues See more
Orthologs
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Genomic context

See Tcp1 in Genome Data Viewer
Location:
17 A1; 17 8.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13135216..13143954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12916329..12925067)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member H Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene predicted gene, 26130 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene acetyl-Coenzyme A acetyltransferase 3 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit alpha
Names
CCT-alpha
T-complex protein 1 subunit alpha A
T-complex protein 1 subunit alpha B
TCP-1-A
TCP-1-B
TCP-1-alpha
t-complex polypeptide 1
tailless complex polypeptide 1A
tailless complex polypeptide 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290712.1NP_001277641.1  T-complex protein 1 subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_001277641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK149611, AK153430, CN725473
    Consensus CDS
    CCDS70760.1
    UniProtKB/Swiss-Prot
    P11983
    Related
    ENSMUSP00000086418.7, ENSMUST00000089024.13
    Conserved Domains (2) summary
    cd03335
    Location:2486
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02340
    Location:2491
    chap_CCT_alpha; T-complex protein 1, alpha subunit
  2. NM_013686.4NP_038714.2  T-complex protein 1 subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_038714.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK149611, AK166966, CN725473
    Consensus CDS
    CCDS28397.1
    UniProtKB/Swiss-Prot
    P11983, Q3UE48
    Related
    ENSMUSP00000116108.2, ENSMUST00000151287.8
    Conserved Domains (2) summary
    cd03335
    Location:9535
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02340
    Location:5540
    chap_CCT_alpha; T-complex protein 1, alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13135216..13143954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)