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Cdk12 cyclin-dependent kinase 12 [ Mus musculus (house mouse) ]

Gene ID: 69131, updated on 5-Jan-2023

Summary

Official Symbol
Cdk12provided by MGI
Official Full Name
cyclin-dependent kinase 12provided by MGI
Primary source
MGI:MGI:1098802
See related
Ensembl:ENSMUSG00000003119 AllianceGenome:MGI:1098802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik
Summary
Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk12 in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98093259..98171926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98202433..98281101)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 38963 Neighboring gene microRNA 5119 Neighboring gene predicted gene, 31194 Neighboring gene predicted gene, 31317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141525

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin K-CDK12 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 12
Names
CDC2-related kinase 7
CDC2-related kinase, arginine/serine-rich
CDC2-related protein kinase 7
cell division cycle 2-related protein kinase 7
cell division protein kinase 12
protein kinase for splicing component
NP_001103096.1
NP_001103098.1
NP_081228.2
XP_006534171.1
XP_011247526.1
XP_011247527.1
XP_030102133.1
XP_030102134.1
XP_030102135.1
XP_030102136.1
XP_036012845.1
XP_036012846.1
XP_036012847.1
XP_036012848.1
XP_036012849.1
XP_036012850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109626.1NP_001103096.1  cyclin-dependent kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_001103096.1

    Status: VALIDATED

    Source sequence(s)
    AA066711, AK049376, AL591205, BC116645
    Consensus CDS
    CCDS48901.1
    UniProtKB/Swiss-Prot
    Q14AX6, Q8R457
    Related
    ENSMUSP00000103162.2, ENSMUST00000107538.2
    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. NM_001109628.1NP_001103098.1  cyclin-dependent kinase 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA066711, AK129237, AL591205, BC116645
    Consensus CDS
    CCDS48902.1
    UniProtKB/Swiss-Prot
    Q14AX6
    Related
    ENSMUSP00000103163.2, ENSMUST00000107539.8
    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  3. NM_026952.2NP_081228.2  cyclin-dependent kinase 12 isoform 3

    See identical proteins and their annotated locations for NP_081228.2

    Status: VALIDATED

    Source sequence(s)
    AA066711, AL591205, BC116645
    Consensus CDS
    CCDS25342.1
    UniProtKB/Swiss-Prot
    Q14AX6
    Related
    ENSMUSP00000003203.8, ENSMUST00000003203.14
    Conserved Domains (2) summary
    smart00220
    Location:7231016
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RNA

  1. NR_175406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205
  2. NR_175407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205
  3. NR_175408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205
  4. NR_175409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205
  5. NR_175478.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591205

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98093259..98171926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246273.1XP_030102133.1  cyclin-dependent kinase 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8R457
    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. XM_006534108.4XP_006534171.1  cyclin-dependent kinase 12 isoform X2

    Conserved Domains (1) summary
    cd07864
    Location:7141015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  3. XM_036156952.1XP_036012845.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (1) summary
    cd07864
    Location:7141015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  4. XM_036156957.1XP_036012850.1  cyclin-dependent kinase 12 isoform X11

    Conserved Domains (1) summary
    cd07864
    Location:7141015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  5. XM_011249224.4XP_011247526.1  cyclin-dependent kinase 12 isoform X6

    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  6. XM_011249225.4XP_011247527.1  cyclin-dependent kinase 12 isoform X10

    See identical proteins and their annotated locations for XP_011247527.1

    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  7. XM_036156956.1XP_036012849.1  cyclin-dependent kinase 12 isoform X10

    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  8. XM_036156955.1XP_036012848.1  cyclin-dependent kinase 12 isoform X9

    Conserved Domains (2) summary
    PRK08691
    Location:11361313
    PRK08691; DNA polymerase III subunits gamma and tau; Validated
    cd07864
    Location:715997
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  9. XM_030246274.2XP_030102134.1  cyclin-dependent kinase 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8R457
    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  10. XM_030246275.2XP_030102135.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  11. XM_036156953.1XP_036012846.1  cyclin-dependent kinase 12 isoform X5

    Conserved Domains (1) summary
    cd07864
    Location:715997
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  12. XM_030246276.2XP_030102136.1  cyclin-dependent kinase 12 isoform X8

    Conserved Domains (1) summary
    cd07864
    Location:7151016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  13. XM_036156954.1XP_036012847.1  cyclin-dependent kinase 12 isoform X7

    Conserved Domains (1) summary
    cd07864
    Location:7141015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12