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CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ]

Gene ID: 51755, updated on 1-Jun-2020

Summary

Official Symbol
CDK12provided by HGNC
Official Full Name
cyclin dependent kinase 12provided by HGNC
Primary source
HGNC:HGNC:24224
See related
Ensembl:ENSG00000167258 MIM:615514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRK7; CRKR; CRKRS
Expression
Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See CDK12 in Genome Data Viewer
Location:
17q12
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39461486..39567560)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37617739..37721398)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 20 Neighboring gene microRNA 548BC Neighboring gene mediator complex subunit 1 Neighboring gene RNA, U6 small nuclear 233, pseudogene Neighboring gene uncharacterized LOC105371770 Neighboring gene uncharacterized LOC105371771

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0904

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II CTD heptapeptide repeat kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation of RNA polymerase II C-terminal domain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation of RNA polymerase II C-terminal domain IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription elongation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cyclin K-CDK12 complex IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear cyclin-dependent protein kinase holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 12
Names
CDC2-related protein kinase 7
Cdc2-related kinase, arginine/serine-rich
cell division cycle 2-related protein kinase 7
cell division protein kinase 12
NP_055898.1
NP_057591.2
XP_005257513.1
XP_005257515.1
XP_011523194.1
XP_011523195.1
XP_011523196.1
XP_011523197.1
XP_011523198.1
XP_011523199.1
XP_011523200.1
XP_011523201.1
XP_011523202.1
XP_011523203.1
XP_011523204.1
XP_011523205.1
XP_011523207.1
XP_011523208.1
XP_011523209.1
XP_016880236.1
XP_016880237.1
XP_016880238.1
XP_016880239.1
XP_016880240.1
XP_016880241.1
XP_016880242.1
XP_024306569.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065324.1 RefSeqGene

    Range
    5001..78059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015083.3NP_055898.1  cyclin-dependent kinase 12 isoform 2

    See identical proteins and their annotated locations for NP_055898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC009283, AK302645, BC150265, BE003756, BM557102
    Consensus CDS
    CCDS45666.1
    UniProtKB/Swiss-Prot
    Q9NYV4
    Related
    ENSP00000407720.2, ENST00000430627.6
    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. NM_016507.4NP_057591.2  cyclin-dependent kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_057591.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
    Source sequence(s)
    AC009283, AF227198, AK302645, BC150265, BE003756, BM557102
    Consensus CDS
    CCDS11337.1
    UniProtKB/Swiss-Prot
    Q9NYV4
    Related
    ENSP00000398880.3, ENST00000447079.5
    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    39461486..39567560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524896.2XP_011523198.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523198.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. XM_011524897.2XP_011523199.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523199.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  3. XM_024450801.1XP_024306569.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  4. XM_011524895.2XP_011523197.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523197.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  5. XM_011524893.2XP_011523195.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523195.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  6. XM_011524894.2XP_011523196.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523196.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  7. XM_011524903.2XP_011523205.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523205.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  8. XM_011524901.2XP_011523203.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523203.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  9. XM_017024748.1XP_016880237.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  10. XM_011524900.2XP_011523202.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523202.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  11. XM_017024747.1XP_016880236.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  12. XM_011524899.2XP_011523201.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523201.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  13. XM_011524898.2XP_011523200.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523200.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  14. XM_017024749.1XP_016880238.1  cyclin-dependent kinase 12 isoform X3

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  15. XM_011524902.2XP_011523204.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523204.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  16. XM_017024752.1XP_016880241.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  17. XM_017024750.1XP_016880239.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  18. XM_017024751.1XP_016880240.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  19. XM_011524907.2XP_011523209.1  cyclin-dependent kinase 12 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  20. XM_011524905.2XP_011523207.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523207.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  21. XM_011524906.2XP_011523208.1  cyclin-dependent kinase 12 isoform X3

    See identical proteins and their annotated locations for XP_011523208.1

    Conserved Domains (1) summary
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  22. XM_011524892.2XP_011523194.1  cyclin-dependent kinase 12 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:727994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:719994
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  23. XM_005257458.4XP_005257515.1  cyclin-dependent kinase 12 isoform X6

    Related
    ENSP00000464641.1, ENST00000584632.5
    Conserved Domains (2) summary
    smart00220
    Location:7271020
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7191020
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  24. XM_017024753.2XP_016880242.1  cyclin-dependent kinase 12 isoform X5

  25. XM_005257456.4XP_005257513.1  cyclin-dependent kinase 12 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:7261019
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:7181019
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
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