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Marchf5 membrane associated ring-CH-type finger 5 [ Mus musculus (house mouse) ]

Gene ID: 69104, updated on 18-Sep-2024

Summary

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Official Symbol
Marchf5provided by MGI
Official Full Name
membrane associated ring-CH-type finger 5provided by MGI
Primary source
MGI:MGI:1915207
See related
Ensembl:ENSMUSG00000023307 AllianceGenome:MGI:1915207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MITOL; March5; Marchv; Rnf153; MARCH-V; 1810015H18Rik; 2310008I22Rik; 2700055A20Rik; 5730499H23Rik; E130202O05Rik
Summary
Predicted to enable GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of cell aging; positive regulation of mitochondrial fission; and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 15.2), CNS E14 (RPKM 13.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 32.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37184939..37201856)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37207540..37224457)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46041 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene RIKEN cDNA A330032B11 gene Neighboring gene predicted gene, 25268 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation†. Zhou Q, et al. Biol Reprod, 2023 Mar 13. PMID 36503987
  2. Identification of highest neurotoxic amyloid-β plaque type showing reduced contact with astrocytes. Mitsubori M, et al. Biochem Biophys Res Commun, 2021 Apr 16. PMID 33667711
  3. Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation. Takeda K, et al. Commun Biol, 2021 Feb 12. PMID 33580194, Free PMC Article
  4. Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Gu H, et al. Nat Commun, 2015 Jun 2. PMID 26033541, Free PMC Article
  5. MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia. Matsuno K, et al. J Biochem, 2020 Sep 1. PMID 32302394

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response.
    Title: MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response.
  2. PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
    Title: PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
  3. Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
    Title: Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
  4. MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING.
    Title: MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING.
  5. Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturationdagger.
    Title: Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation†.
  6. Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-beta oligomer generation.
    Title: Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.
  7. A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis.
    Title: A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis.
  8. MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
    Title: MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
  9. Results showed that mitochondrial abnormalities in MITOL KO brain induced mild behavioral changes. MITOL KO brain also displayed enhanced oxidative stress, which may result from increased electron leakage from mitochondria. The reduced ER-mitochondria tethering and excessive mitochondrial fission may trigger neuroinflammation through oxidative stress.
    Title: MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
  10. MARCH5 is regulated by peroxisome proliferator-activated receptor-gamma (PPARgamma) during adipogenesis and is correlated with fat mass across a panel of genetically diverse mouse strains, in ob/ob mice, and in humans. Furthermore, manipulation of MARCH5 expression in vitro and in vivo alters mitochondrial function, affects cellular metabolism, and leads to differential regulation of several metabolic genes
    Title: The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130121, MGC130122

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF5
Names
E3 ubiquitin-protein ligase MARCH5
RING-type E3 ubiquitin transferase MARCH5
RING-type E3 ubiquitin transferase MARCHF5
membrane-associated RING finger protein 5
membrane-associated RING-CH protein V
membrane-associated ring finger (C3HC4) 5
ring finger protein 153
NP_001157808.1
NP_001157809.1
NP_001365726.1
NP_001365727.1
NP_081590.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164336.1 → NP_001157808.1  E3 ubiquitin-protein ligase MARCHF5 isoform 2

    See identical proteins and their annotated locations for NP_001157808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK007511, AK009364, BY070559, CX733941
    Consensus CDS
    CCDS50427.1
    UniProtKB/TrEMBL
    A0A0R4J1H0
    Related
    ENSMUSP00000108010.2, ENSMUST00000112391.8
    Conserved Domains (1) summary
    cd16701
    Location:12 → 72
    RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

  2. NM_001164337.1 → NP_001157809.1  E3 ubiquitin-protein ligase MARCHF5 isoform 3

    See identical proteins and their annotated locations for NP_001157809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC161238, AK007511, AK009364, AK021403, BY070559
    Conserved Domains (1) summary
    smart00744
    Location:14 → 69
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. NM_001378797.1 → NP_001365726.1  E3 ubiquitin-protein ligase MARCHF5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161238
    Conserved Domains (1) summary
    cd16701
    Location:12 → 72
    RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

  4. NM_001378798.1 → NP_001365727.1  E3 ubiquitin-protein ligase MARCHF5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161238

  5. NM_027314.3 → NP_081590.3  E3 ubiquitin-protein ligase MARCHF5 isoform 1

    See identical proteins and their annotated locations for NP_081590.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC161238, AK003478, AK009364, AK017741, BC132455, BY070559
    Consensus CDS
    CCDS29776.1
    UniProtKB/Swiss-Prot
    Q3KNM2, Q3KNM3, Q6P230, Q9CPS3, Q9CTI6
    UniProtKB/TrEMBL
    A2RTC8
    Related
    ENSMUSP00000024078.8, ENSMUST00000024078.15
    Conserved Domains (1) summary
    cd16701
    Location:12 → 72
    RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    37184939..37201856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNM2.1 GenPept UniProtKB/Swiss-Prot:Q3KNM2

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