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MARCHF5 membrane associated ring-CH-type finger 5 [ Homo sapiens (human) ]

Gene ID: 54708, updated on 6-Sep-2020

Summary

Official Symbol
MARCHF5provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 5provided by HGNC
Primary source
HGNC:HGNC:26025
See related
Ensembl:ENSG00000198060 MIM:610637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MITOL; MARCH5; RNF153; MARCH-V
Summary
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 13.2), prostate (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See MARCHF5 in Genome Data Viewer
Location:
10q23.32-q23.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (92291164..92353964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94050920..94113721)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 8 Neighboring gene NHP2 ribonucleoprotein pseudogene 1 Neighboring gene RNY3 pseudogene 12 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 9 Neighboring gene insulin degrading enzyme

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF5
Names
E3 ubiquitin-protein ligase MARCH5
RING-type E3 ubiquitin transferase MARCH5
RING-type E3 ubiquitin transferase MARCHF5
membrane associated ring finger 5
membrane-associated RING finger protein 5
membrane-associated RING-CH protein V
membrane-associated ring finger (C3HC4) 5
mitochondrial ubiquitin ligase
ring finger protein 153
NP_060294.1
XP_011538188.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017824.5NP_060294.1  E3 ubiquitin-protein ligase MARCHF5

    See identical proteins and their annotated locations for NP_060294.1

    Status: VALIDATED

    Source sequence(s)
    AK000452, BC015480, BE393612
    Consensus CDS
    CCDS7420.1
    UniProtKB/Swiss-Prot
    Q9NX47
    Related
    ENSP00000351813.2, ENST00000358935.3
    Conserved Domains (1) summary
    cd16701
    Location:1272
    RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    92291164..92353964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539886.3XP_011538188.1  E3 ubiquitin-protein ligase MARCHF5 isoform X1

    See identical proteins and their annotated locations for XP_011538188.1

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