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BTF3 basic transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 689, updated on 7-Jun-2020

Summary

Official Symbol
BTF3provided by HGNC
Official Full Name
basic transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:1125
See related
Ensembl:ENSG00000145741 MIM:602542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NACB; BTF3a; BTF3b; BETA-NAC
Summary
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 354.7), bone marrow (RPKM 186.5) and 25 other tissues See more
Orthologs

Genomic context

See BTF3 in Genome Data Viewer
Location:
5q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (73498425..73505623)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (72794250..72801448)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene forkhead box D1 Neighboring gene long intergenic non-protein coding RNA 1386 Neighboring gene FUN14 domain containing 2 pseudogene 1 Neighboring gene ankyrin repeat family A member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of basic transcription factor 3 (BTF3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nascent polypeptide-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
polysomal ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor BTF3
Names
NAC-beta
RNA polymerase B transcription factor 3
nascent polypeptide-associated complex subunit beta
nascent-polypeptide-associated complex beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037637.1NP_001032726.1  transcription factor BTF3 isoform A

    See identical proteins and their annotated locations for NP_001032726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    BG182166, BU661989, BX359147
    Consensus CDS
    CCDS34185.1
    UniProtKB/Swiss-Prot
    P20290
    Related
    ENSP00000369965.3, ENST00000380591.7
    Conserved Domains (1) summary
    pfam01849
    Location:93140
    NAC; NAC domain
  2. NM_001207.4NP_001198.2  transcription factor BTF3 isoform B

    See identical proteins and their annotated locations for NP_001198.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in translation initiation at a downstream AUG and a protein (isoform B) with a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    BC008062, BG182166, BU661989
    Consensus CDS
    CCDS4019.1
    UniProtKB/Swiss-Prot
    P20290
    Related
    ENSP00000338516.8, ENST00000335895.12
    Conserved Domains (1) summary
    pfam01849
    Location:4396
    NAC; NAC domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    73498425..73505623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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