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Btf3 basic transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 218490, updated on 8-Feb-2024

Summary

Official Symbol
Btf3provided by MGI
Official Full Name
basic transcription factor 3provided by MGI
Primary source
MGI:MGI:1202875
See related
Ensembl:ENSMUSG00000021660 AllianceGenome:MGI:1202875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700054E11Rik
Summary
Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol and polysomal ribosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 136.7), placenta adult (RPKM 125.5) and 26 other tissues See more
Orthologs
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Genomic context

See Btf3 in Genome Data Viewer
Location:
13 D1; 13 51.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98446405..98453514, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98309897..98317006, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat family A member 2 Neighboring gene predicted gene 21976 Neighboring gene STARR-seq mESC enhancer starr_35417 Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene predicted gene 9828 Neighboring gene STARR-seq mESC enhancer starr_35419 Neighboring gene forkhead box D1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of nascent polypeptide-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nascent polypeptide-associated complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor BTF3
Names
NAC-beta
RNA polymerase B transcription factor 3
nascent polypeptide-associated complex subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170540.1NP_001164011.1  transcription factor BTF3 isoform 2

    See identical proteins and their annotated locations for NP_001164011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK139664, BC064010, CJ073405
    Consensus CDS
    CCDS49340.1
    UniProtKB/TrEMBL
    Q3UJR8
    Related
    ENSMUSP00000118093.2, ENSMUST00000152704.8
    Conserved Domains (1) summary
    cd22055
    Location:9125
    NAC_BTF3; basal transcription factor BTF3
  2. NM_145455.3NP_663430.2  transcription factor BTF3 isoform 1

    See identical proteins and their annotated locations for NP_663430.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BC064010
    Consensus CDS
    CCDS26714.1
    UniProtKB/Swiss-Prot
    Q64152, Q64153, Q6GU63, Q6P3F3
    Related
    ENSMUSP00000022163.9, ENSMUST00000022163.15
    Conserved Domains (1) summary
    pfam01849
    Location:85138
    NAC; NAC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    98446405..98453514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)