Rasl11a RAS-like, family 11, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasl11aprovided by MGI
Official Full Name: RAS-like, family 11, member Aprovided by MGI
Primary source: MGI:MGI:1916145
See related: Ensembl:ENSMUSG00000029641 AllianceGenome:MGI:1916145
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110065D03Rik
Summary: Predicted to enable G protein activity and GTP binding activity. Involved in positive regulation of transcription by RNA polymerase I. Located in nucleolus. Orthologous to human RASL11A (RAS like family 11 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 9.8), lung adult (RPKM 9.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 86.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (146781881..146784536)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (146845071..146847726)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region.
Title: Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-like protein family member 11A

NP_081140.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026864.1 → NP_081140.1 ras-like protein family member 11A

See identical proteins and their annotated locations for NP_081140.1

Status: PROVISIONAL

Source sequence(s)

BK001706

Consensus CDS

CCDS39396.1

UniProtKB/Swiss-Prot

Q148R6, Q6IMB1

Related

ENSMUSP00000031646.8, ENSMUST00000031646.8

Conserved Domains (2) summary

smart00010
Location:26 → 198

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04146
Location:29 → 196

RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families