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Foxk2 forkhead box K2 [ Mus musculus (house mouse) ]

Gene ID: 68837, updated on 5-Jan-2023

Summary

Official Symbol
Foxk2provided by MGI
Official Full Name
forkhead box K2provided by MGI
Primary source
MGI:MGI:1916087
See related
Ensembl:ENSMUSG00000039275 AllianceGenome:MGI:1916087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ILF; Ilf1; 1110054H05Rik; 5730434B08Rik; 6230415M23Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; genitourinary system; and nervous system. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 17.4), ovary adult (RPKM 17.3) and 28 other tissues See more
Orthologs
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Genomic context

See Foxk2 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121150805..121200726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121259987..121309900)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing Neighboring gene cytochrome b 245 chaperone 1 Neighboring gene nuclear prelamin A recognition factor Neighboring gene WD repeat domain 45B Neighboring gene Rab40B, member RAS oncogene family Neighboring gene microRNA 7236

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein K2
Names
cellular transcription factor ILF-1
interleukin enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080932.3NP_001074401.2  forkhead box protein K2 isoform 1

    See identical proteins and their annotated locations for NP_001074401.2

    Status: VALIDATED

    Source sequence(s)
    AL808021, EU882160
    Consensus CDS
    CCDS36393.2
    UniProtKB/Swiss-Prot
    B5AZX0, Q3UCQ1
    Related
    ENSMUSP00000101719.2, ENSMUST00000106113.2
    Conserved Domains (2) summary
    cd00060
    Location:41145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:249335
    Forkhead; Forkhead domain
  2. NM_001363033.1NP_001349962.1  forkhead box protein K2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK150439, AL808021
    Conserved Domains (2) summary
    cd00060
    Location:41145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:249334
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121150805..121200726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156941.1XP_036012834.1  forkhead box protein K2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:341562
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:41145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd20055
    Location:247344
    FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
  2. XM_036156942.1XP_036012835.1  forkhead box protein K2 isoform X6

    Conserved Domains (2) summary
    cd00060
    Location:41145
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd20055
    Location:247344
    FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
  3. XM_011249218.2XP_011247520.1  forkhead box protein K2 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:380683
    PHA03247; large tegument protein UL36; Provisional
    COG5025
    Location:175381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287373
    Forkhead; Forkhead domain
  4. XM_011249219.2XP_011247521.1  forkhead box protein K2 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:380657
    PHA03247; large tegument protein UL36; Provisional
    COG5025
    Location:175381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287373
    Forkhead; Forkhead domain
  5. XM_011249220.2XP_011247522.1  forkhead box protein K2 isoform X4

    Conserved Domains (3) summary
    COG5025
    Location:175381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287373
    Forkhead; Forkhead domain
  6. XM_011249221.2XP_011247523.1  forkhead box protein K2 isoform X5

    Conserved Domains (3) summary
    COG5025
    Location:175381
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:41124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:287373
    Forkhead; Forkhead domain

RNA

  1. XR_004937017.1 RNA Sequence

  2. XR_003949496.2 RNA Sequence

  3. XR_004937014.1 RNA Sequence

  4. XR_879734.2 RNA Sequence

  5. XR_004937015.1 RNA Sequence

  6. XR_003949497.2 RNA Sequence

  7. XR_004937016.1 RNA Sequence

  8. XR_004937018.1 RNA Sequence