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FOXK2 forkhead box K2 [ Homo sapiens (human) ]

Gene ID: 3607, updated on 23-Dec-2018

Summary

Official Symbol
FOXK2provided by HGNC
Official Full Name
forkhead box K2provided by HGNC
Primary source
HGNC:HGNC:6036
See related
Ensembl:ENSG00000141568 MIM:147685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILF; ILF1; ILF-1
Summary
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.2), brain (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See FOXK2 in Genome Data Viewer
Location:
17q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (82519718..82604607)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80477594..80562483)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371941 Neighboring gene nuclear prelamin A recognition factor Neighboring gene transfer RNA-iMet (CAT) 1-8 Neighboring gene uncharacterized LOC105371942 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 9 Neighboring gene WD repeat domain 45B Neighboring gene RAB40B, member RAS oncogene family Neighboring gene microRNA 4525

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
forkhead box protein K2
Names
FOXK1
cellular transcription factor ILF-1
interleukin enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004514.4NP_004505.2  forkhead box protein K2

    See identical proteins and their annotated locations for NP_004505.2

    Status: REVIEWED

    Source sequence(s)
    AC124283, AC124287, U58196
    Consensus CDS
    CCDS11813.1
    UniProtKB/Swiss-Prot
    Q01167
    Related
    ENSP00000335677.5, ENST00000335255.9
    Conserved Domains (3) summary
    COG5025
    Location:180577
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00060
    Location:47154
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:258344
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    82519718..82604607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450739.1XP_024306507.1  forkhead box protein K2 isoform X1

    Conserved Domains (2) summary
    pfam00250
    Location:271
    Forkhead; Forkhead domain
    cl26464
    Location:78381
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001752506.1 RNA Sequence

  2. XR_933935.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181430.1: Suppressed sequence

    Description
    NM_181430.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_181431.1: Suppressed sequence

    Description
    NM_181431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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