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Rreb1 ras responsive element binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 68750, updated on 8-Nov-2022

Summary

Official Symbol
Rreb1provided by MGI
Official Full Name
ras responsive element binding protein 1provided by MGI
Primary source
MGI:MGI:2443664
See related
Ensembl:ENSMUSG00000039087 AllianceGenome:MGI:2443664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110037N09Rik; B930013M22Rik
Summary
Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of brown fat cell differentiation. Acts upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in fibrillar center and nuclear speck. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and pancreas epithelium. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 5.6), colon adult (RPKM 5.2) and 28 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Rreb1 in Genome Data Viewer
Location:
13; 13 A3.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37962362..38135981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (37778382..37952005)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40918 Neighboring gene predicted gene, 31600 Neighboring gene predicted gene, 46411 Neighboring gene predicted gene, 52041 Neighboring gene signal sequence receptor, alpha Neighboring gene cancer antigen 1 Neighboring gene RIO kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-responsive element-binding protein 1
Names
RAS-responsive zinc finger transcription factor RREB

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039188.2NP_001034277.1  ras-responsive element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001034277.1

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    Consensus CDS
    CCDS36634.1
    UniProtKB/Swiss-Prot
    Q3UH06
    Related
    ENSMUSP00000105866.3, ENSMUST00000110237.9
    Conserved Domains (3) summary
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:111136
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001177868.2NP_001171339.1  ras-responsive element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001171339.1

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    Consensus CDS
    CCDS36634.1
    UniProtKB/Swiss-Prot
    Q3UH06
    Related
    ENSMUSP00000121211.2, ENSMUST00000149745.8
    Conserved Domains (3) summary
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:111136
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001177869.2NP_001171340.1  ras-responsive element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001171340.1

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    Consensus CDS
    CCDS49238.1
    UniProtKB/Swiss-Prot
    Q3UH06
    Related
    ENSMUSP00000049265.8, ENSMUST00000037232.8
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  4. NM_001404757.1NP_001391686.1  ras-responsive element-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    UniProtKB/Swiss-Prot
    Q66JZ8
  5. NM_001404758.1NP_001391687.1  ras-responsive element-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    UniProtKB/Swiss-Prot
    Q66JZ8
  6. NM_001404759.1NP_001391688.1  ras-responsive element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
  7. NM_001404760.1NP_001391689.1  ras-responsive element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
  8. NM_026830.3NP_081106.1  ras-responsive element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081106.1

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477
    Consensus CDS
    CCDS36634.1
    UniProtKB/Swiss-Prot
    Q3UH06
    Related
    ENSMUSP00000105867.3, ENSMUST00000110238.10
    Conserved Domains (3) summary
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:111136
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_033218.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010477
    Related
    ENSMUST00000124268.8
  2. NR_033615.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022682, CT010477

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    37962362..38135981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516757.5XP_006516820.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516820.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  2. XM_030247397.2XP_030103257.1  ras-responsive element-binding protein 1 isoform X4

    Conserved Domains (8) summary
    smart00355
    Location:11711191
    ZnF_C2H2; zinc finger
    sd00017
    Location:1737
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:15201542
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:299590
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15061530
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:124146
    zf-C2H2_4; C2H2-type zinc finger
    pfam13909
    Location:587611
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:14931514
    zf-C2H2_6; C2H2-type zinc finger
  3. XM_036158150.1XP_036014043.1  ras-responsive element-binding protein 1 isoform X5

    Conserved Domains (7) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:14971517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:14951517
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:111136
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
  4. XM_006516754.5XP_006516817.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516817.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  5. XM_030247395.2XP_030103255.1  ras-responsive element-binding protein 1 isoform X4

    Conserved Domains (8) summary
    smart00355
    Location:11711191
    ZnF_C2H2; zinc finger
    sd00017
    Location:1737
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:15201542
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:299590
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15061530
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:124146
    zf-C2H2_4; C2H2-type zinc finger
    pfam13909
    Location:587611
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:14931514
    zf-C2H2_6; C2H2-type zinc finger
  6. XM_030247396.2XP_030103256.1  ras-responsive element-binding protein 1 isoform X4

    Conserved Domains (8) summary
    smart00355
    Location:11711191
    ZnF_C2H2; zinc finger
    sd00017
    Location:1737
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:15201542
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:299590
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15061530
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:124146
    zf-C2H2_4; C2H2-type zinc finger
    pfam13909
    Location:587611
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:14931514
    zf-C2H2_6; C2H2-type zinc finger
  7. XM_006516749.3XP_006516812.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516812.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Related
    ENSMUSP00000115599.2, ENSMUST00000128570.9
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  8. XM_006516758.3XP_006516821.1  ras-responsive element-binding protein 1 isoform X2

    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:15511571
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:15491571
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:12651290
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
  9. XM_006516759.3XP_006516822.1  ras-responsive element-binding protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (6) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15341558
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    NF033845
    Location:14261671
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  10. XM_030247398.2XP_030103258.1  ras-responsive element-binding protein 1 isoform X5

    Conserved Domains (7) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:14971517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:14951517
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:111136
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
  11. XM_006516750.3XP_006516813.1  ras-responsive element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  12. XM_036158149.1XP_036014042.1  ras-responsive element-binding protein 1 isoform X3

    Conserved Domains (6) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:15341558
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    NF033845
    Location:14261671
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  13. XM_011244341.4XP_011242643.1  ras-responsive element-binding protein 1 isoform X4

    Conserved Domains (8) summary
    smart00355
    Location:11711191
    ZnF_C2H2; zinc finger
    sd00017
    Location:1737
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:15201542
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:299590
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15061530
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:124146
    zf-C2H2_4; C2H2-type zinc finger
    pfam13909
    Location:587611
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:14931514
    zf-C2H2_6; C2H2-type zinc finger
  14. XM_006516756.4XP_006516819.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516819.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  15. XM_006516751.4XP_006516814.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516814.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  16. XM_006516752.3XP_006516815.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516815.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger
  17. XM_006516753.5XP_006516816.1  ras-responsive element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516816.1

    UniProtKB/Swiss-Prot
    Q3UH06
    Conserved Domains (8) summary
    smart00355
    Location:12531273
    ZnF_C2H2; zinc finger
    COG5048
    Location:64244
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6888
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16021624
    zf-C2H2; Zinc finger, C2H2 type
    pfam04625
    Location:381672
    DEC-1_N; DEC-1 protein, N-terminal region
    pfam13465
    Location:15881612
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:669693
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam13912
    Location:15751596
    zf-C2H2_6; C2H2-type zinc finger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013392.3: Suppressed sequence

    Description
    NM_001013392.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.