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TAF4 TATA-box binding protein associated factor 4 [ Homo sapiens (human) ]

Gene ID: 6874, updated on 6-Jan-2019

Summary

Official Symbol
TAF4provided by HGNC
Official Full Name
TATA-box binding protein associated factor 4provided by HGNC
Primary source
HGNC:HGNC:11537
See related
Ensembl:ENSG00000130699 MIM:601796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.8), ovary (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See TAF4 in Genome Data Viewer
Location:
20q13.33
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (61974798..62065810, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60549854..60640866, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cadherin 4 Neighboring gene uncharacterized LOC100128310 Neighboring gene uncharacterized LOC105372704 Neighboring gene microRNA 1257 Neighboring gene uncharacterized LOC105372705 Neighboring gene ribosomal protein L17 pseudogene 48 Neighboring gene uncharacterized LOC105372706 Neighboring gene microRNA 3195 Neighboring gene LSM family member 14B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 4
Names
RNA polymerase II TBP-associated factor subunit C
TAF(II)130
TAF(II)135
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD
TAFII-130
TAFII-135
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
TBP-associated factor 4
transcription initiation factor TFIID 130 kDa subunit
transcription initiation factor TFIID 135 kD subunit
transcription initiation factor TFIID 135 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003185.3NP_003176.2  transcription initiation factor TFIID subunit 4

    See identical proteins and their annotated locations for NP_003176.2

    Status: REVIEWED

    Source sequence(s)
    AL137077, U75308, Y11354
    Consensus CDS
    CCDS33500.1
    UniProtKB/Swiss-Prot
    O00268
    Related
    ENSP00000252996.3, ENST00000252996.8
    Conserved Domains (2) summary
    pfam05236
    Location:8341082
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:592675
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    61974798..62065810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187623.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    85385..118232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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