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Taf4 TATA-box binding protein associated factor 4 [ Mus musculus (house mouse) ]

Gene ID: 228980, updated on 8-Dec-2022

Summary

Official Symbol
Taf4provided by MGI
Official Full Name
TATA-box binding protein associated factor 4provided by MGI
Primary source
MGI:MGI:2152346
See related
Ensembl:ENSMUSG00000039117 AllianceGenome:MGI:2152346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Taf4a; 135kDa; Taf2c1; TAFII130; TAFII135
Summary
Enables DNA binding activity. Acts upstream of or within ovarian follicle development and transcription, DNA-templated. Located in nucleus. Is expressed in brain; spinal cord; tail; and thymus. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 9.9), colon adult (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Taf4 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179553939..179618519, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (179912146..179976646, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36004 Neighboring gene cadherin 4 Neighboring gene predicted gene, 36066 Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene LSM family member 14B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in monoubiquitinated histone H2A deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in monoubiquitinated histone deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 4
Names
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081092.2NP_001074561.1  transcription initiation factor TFIID subunit 4

    Status: VALIDATED

    Source sequence(s)
    AL663067
    Consensus CDS
    CCDS38373.1
    UniProtKB/TrEMBL
    E9QAP7
    Related
    ENSMUSP00000038610.8, ENSMUST00000041618.13
    Conserved Domains (2) summary
    pfam05236
    Location:7911039
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:550633
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179553939..179618519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500588.2XP_006500651.2  transcription initiation factor TFIID subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BPN6
    Related
    ENSMUSP00000153863.2, ENSMUST00000227325.2
    Conserved Domains (2) summary
    pfam05236
    Location:7791027
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:550633
    TAFH; NHR1 homology to TAF

RNA

  1. XR_004940192.1 RNA Sequence

  2. XR_004940194.1 RNA Sequence