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TAF1 TATA-box binding protein associated factor 1 [ Homo sapiens (human) ]

Gene ID: 6872, updated on 26-Nov-2021

Summary

Official Symbol
TAF1provided by HGNC
Official Full Name
TATA-box binding protein associated factor 1provided by HGNC
Primary source
HGNC:HGNC:11535
See related
Ensembl:ENSG00000147133 MIM:313650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; MRXS33; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in thyroid (RPKM 5.8), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See TAF1 in Genome Data Viewer
Location:
Xq13.1
Exon count:
45
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (71366220..71530525)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70586207..70750375)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ZCRB1 pseudogene 1 Neighboring gene RHOG family member 2, pseudogene Neighboring gene PABPN1 pseudogene 1 Neighboring gene inhibitor of growth family, X-linked (pseudogene) Neighboring gene SOCS6 pseudogene 1 Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene germ cell nuclear acidic peptidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stimulates the phosphorylation of TFIIF by TAFII250 during Tat-mediated transcription of the HIV-1 LTR promoter PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat HIV-1 Tat binding to TAFII250 inhibits TAFII250 histone acetyltransferase activity and TAFII250-dependent transcription of the MHC class I and beta2-microglobulin promoters PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat Amino acids (aa) 67-101 (C-term. domain) of HIV-1 Tat bind to aa 848-1279 of TAFII250, while Tat aa 18-36 (cysteine-rich domain) and 36-56 (includes basic domain) bind to TAFII250 aa 885-984 (AT domain) and 1120-1279 (Rap74 binding domain), respectively PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to H3K27me3 modified histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase I general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II general transcription initiation factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables RNA polymerase II general transcription initiation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables acetyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables histone acetyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of androgen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle G1/S phase transition TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription factor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription initiation from RNA polymerase I promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription initiation from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription initiation from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus EXP
Inferred from Experiment
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIID complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription factor TFIID complex TAS
Traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 1
Names
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBP-associated factor 250 kDa
cell cycle gene 1 protein
cell cycle, G1 phase defect
complementation of cell cycle block, G1-to-S
transcription factor TFIID p250 polypeptide
NP_001273003.2
NP_004597.3
NP_620278.2
XP_005262352.1
XP_005262353.1
XP_005262354.1
XP_005262357.1
XP_024308197.1
XP_024308198.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012771.2 RefSeqGene

    Range
    4976..104742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286074.2NP_001273003.2  transcription initiation factor TFIID subunit 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3, also known as neuron specific isoform or N-TAF1).
    Source sequence(s)
    AB300418, AL590763
    Consensus CDS
    CCDS69783.1
    Related
    ENSP00000276072.5, ENST00000276072.9
    Conserved Domains (4) summary
    cd05511
    Location:15081620
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:866
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5661029
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12621297
    zf-CCHC_6; Zinc knuckle
  2. NM_004606.5NP_004597.3  transcription initiation factor TFIID subunit 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3, resulting in an isoform (1) that is 2 aa shorter than isoform 3. The exon combination of this variant is supported by mRNA annotation on DNA accession AY623109.1.
    Source sequence(s)
    AB300418, AL590763
    Consensus CDS
    CCDS14412.1
    Related
    ENSP00000406549.2, ENST00000423759.6
    Conserved Domains (5) summary
    cd05511
    Location:15081620
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:866
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5661029
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12621297
    zf-CCHC_6; Zinc knuckle
    NF033845
    Location:16361872
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  3. NM_138923.4NP_620278.2  transcription initiation factor TFIID subunit 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AL590763, D90359
    Consensus CDS
    CCDS35325.1
    Related
    ENSP00000362895.5, ENST00000373790.9
    Conserved Domains (4) summary
    cd05511
    Location:14871599
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:866
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5451008
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12411276
    zf-CCHC_6; Zinc knuckle

RNA

  1. NR_104387.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as 2a) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AJ549248.3 and data in PMID: 12928496.
    Source sequence(s)
    AB300418, AJ549248, AL590763
  2. NR_104388.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as 2b) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AJ549249.2 and data in PMID: 12928496.
    Source sequence(s)
    AB300418, AJ549249, AL590763
  3. NR_104389.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as 2c) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AJ549250.3 and data in PMID: 12928496.
    Source sequence(s)
    AB300418, AJ549250, AL590763
  4. NR_104390.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as 2d) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AJ555148.2 and data in PMID: 12928496.
    Source sequence(s)
    AB300418, AJ555148, AL590763
  5. NR_104391.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as 2e) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AJ555149.2 and data in PMID: 12928496.
    Source sequence(s)
    AB300418, AJ555149, AL590763
  6. NR_104392.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as 2f) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AM711892.1 and data in PMID: 17952504.
    Source sequence(s)
    AB300418, AJ549248, AL590763, AM711892
  7. NR_104393.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as 2g) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AM711893.1 and data in PMID: 17952504.
    Source sequence(s)
    AB300418, AJ549248, AL590763, AM711893
  8. NR_104394.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as 2h) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AM711894.1 and data in PMID: 17952504.
    Source sequence(s)
    AB300418, AJ549248, AL590763, AM711894
  9. NR_104395.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as 2i) includes a combination of TAF1 and DYT3 exons, and it thus contains alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). The 5' exon structure of this transcript is inferred from transcript alignments, while the 3' exon structure is supported by accession AM711895.1 and data in PMID: 17952504.
    Source sequence(s)
    AB300418, AJ549248, AL590763, AM711895
  10. NR_104396.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as 3) includes independently transcribed DYT3 exons only and it thus lacks similarity to variant 3, but it shares DYT3 exon structure with variants 4 through 12. This variant is represented as non-coding because it lacks the entire coding region found in variant 3. This variant is supported by accession AJ549246.2 and data in PMIDs: 12928496 and 23184149.
    Source sequence(s)
    AJ549246

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    71366220..71530525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262297.4XP_005262354.1  transcription initiation factor TFIID subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_005262354.1

    UniProtKB/Swiss-Prot
    P21675
    Conserved Domains (5) summary
    cd05511
    Location:15071619
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:3386
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5651027
    DUF3591; Protein of unknown function (DUF3591)
    pfam14797
    Location:17531844
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    pfam15288
    Location:12611296
    zf-CCHC_6; Zinc knuckle
  2. XM_005262295.1XP_005262352.1  transcription initiation factor TFIID subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_005262352.1

    Related
    ENSP00000506996.1, ENST00000683782.1
    Conserved Domains (5) summary
    cd05511
    Location:15281640
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:3386
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5861048
    DUF3591; Protein of unknown function (DUF3591)
    pfam14797
    Location:17741865
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    pfam15288
    Location:12821317
    zf-CCHC_6; Zinc knuckle
  3. XM_005262296.1XP_005262353.1  transcription initiation factor TFIID subunit 1 isoform X2

    Conserved Domains (5) summary
    cd05511
    Location:15271639
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:3386
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5861048
    DUF3591; Protein of unknown function (DUF3591)
    pfam14797
    Location:17731864
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    pfam15288
    Location:12811316
    zf-CCHC_6; Zinc knuckle
  4. XM_024452430.1XP_024308198.1  transcription initiation factor TFIID subunit 1 isoform X5

    Conserved Domains (5) summary
    cd05511
    Location:14061517
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2986
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5861049
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12821317
    zf-CCHC_6; Zinc knuckle
    cl02556
    Location:15281604
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  5. XM_005262300.2XP_005262357.1  transcription initiation factor TFIID subunit 1 isoform X6

    Related
    ENSP00000506729.1, ENST00000683715.1
    Conserved Domains (2) summary
    pfam09247
    Location:3386
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:586999
    DUF3591; Protein of unknown function (DUF3591)
  6. XM_024452429.1XP_024308197.1  transcription initiation factor TFIID subunit 1 isoform X4

    Related
    ENSP00000507280.1, ENST00000683668.1
    Conserved Domains (5) summary
    cd05511
    Location:14011513
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam04147
    Location:15831688
    Nop14; Nop14-like family
    pfam12157
    Location:459922
    DUF3591; Protein of unknown function (DUF3591)
    pfam14797
    Location:16471738
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    pfam15288
    Location:11551190
    zf-CCHC_6; Zinc knuckle

RNA

  1. XR_938407.1 RNA Sequence

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