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Serhl serine hydrolase-like [ Mus musculus (house mouse) ]

Gene ID: 68607, updated on 5-Mar-2024

Summary

Official Symbol
Serhlprovided by MGI
Official Full Name
serine hydrolase-likeprovided by MGI
Primary source
MGI:MGI:1890404
See related
Ensembl:ENSMUSG00000058586 AllianceGenome:MGI:1890404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610008B10Rik; 1110019M09Rik
Summary
Predicted to enable hydrolase activity. Located in cytoplasmic vesicle. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 23.5), colon adult (RPKM 16.7) and 28 other tissues See more
Orthologs
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Genomic context

See Serhl in Genome Data Viewer
Location:
15 E1; 15 39.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82984394..83000876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83100192..83116676)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Nfat activating molecule with ITAM motif 1 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene predicted gene, 32620 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene RNA U12, small nuclear

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
serine hydrolase-like protein
Names
SHL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023475.3NP_075964.1  serine hydrolase-like protein

    See identical proteins and their annotated locations for NP_075964.1

    Status: VALIDATED

    Source sequence(s)
    AK003827, BC064069, BY082798
    Consensus CDS
    CCDS49682.1
    UniProtKB/Swiss-Prot
    Q9DCZ8, Q9EPB5
    UniProtKB/TrEMBL
    Q3U3G8, Q80XK9
    Related
    ENSMUSP00000077345.5, ENSMUST00000078218.11
    Conserved Domains (2) summary
    COG0596
    Location:15303
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:28129
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82984394..83000876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248725.2XP_030104585.1  serine hydrolase-like protein isoform X1

RNA

  1. XR_384036.4 RNA Sequence