Conserved Protein Domain Family
Abhydrolase_5

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pfam12695: Abhydrolase_5 (this model, PSSM-Id:289465 is obsolete and has been replaced by 315383)
Alpha/beta hydrolase family
This family contains a diverse range of alpha/beta hydrolase enzymes.
Statistics
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PSSM-Id: 289465
View PSSM: pfam12695
Aligned: 305 rows
Threshold Bit Score: 34.6281
Threshold Setting Gi: 123142565
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74691106   50 LIVLVHGSLSHKNAiYQPLlAHCLAELGYHSLRL-----------DFRGLGD-S--EDVRd------------pKLGRtI 103
gi 499849571  49 ACVVYHGAWAAKEG-KLGV-YSALTARGWAVVIP-----------DAALHGE-R--LKETpp----------glQAREyV 102
gi 506276259  21 TVLLIGGTCLTTLN-WQGW-ISRYTARGYSVIAT-----------AAPLPPS-TdcLGPR--------------DWAQvA 72
gi 506375408   9 TIILVHGFWVTPRS-WEHW-ISRYEARGYRVIAP-----------AYPGFEVeVesLNQDptpieqvtvpqiiaHLEDiV 75
gi 501372783  37 NIVLVHGAWVDGSG-WKPV-YDILAKDGYHVSVV-----------QEPLTSL-D--DDVA--------------ATKRvL 86
gi 750256997  36 NIVLVHGAWADGSG-WKGV-YDILVKDGYNVSIV-----------QEPETSF-K--EDVA--------------ATKRvL 85
gi 806926426  30 NIVLVHGAWVDGSG-WKPV-YEILTKEGFRVTMV-----------QEPETSF-A--DDVT--------------AAKRiL 79
gi 501553767  27 TVVLVHGAFADSSS-WNGV-VEILRKDGFPVVAA-----------ANPLRSV-S--NDAA--------------YVSDvV 76
gi 145235011   7 SIVVVPGAYALPDL-YVRV-TTRLASLGYEVHTIrlss---vapsDGPLPEP-G--TMYD--------------DAAViA 64
gi 738419039  54 LIYLQHGMLASASF-YSAT-AAYLAEKTHSIVVAptltwnvldteNYPLLLP-S--THRA--------------VAELfT 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74691106  104 EEdihdiktvykatqeaqICAnlfETESItfhAIVGHSRGVLAMFDFALsiapsiipilvncs----------------- 166
gi 499849571 103 WEsvrqtvte-apalldtLAEt-fGPVSV---CVTGSSMGGYVTQTLAR------------------------------- 146
gi 506276259  73 SVlt------------yyERLlvtIPQPP---ILIGHCFGGVIAQLLLDrgfgaag------------------------ 113
gi 506375408  76 Q------------------SL----ATPP---ILMGHSAGGVFVQRLLDrglgavgvamnsaptegvlvapfsqlkstfp 130
gi 501372783  87 DG-----------------QD---G--PV---ILVGHSYGGSVITE-AG------------------------------- 109
gi 750256997  86 AQ-----------------QA-----GQC---ILVAHSYGGSVITE-AG------------------------------- 108
gi 806926426  80 DL-----------------QD---G--PT---LLVGHSYGGSIITE-AG------------------------------- 102
gi 501553767  77 AS-----------------IA---G--PV---VLVGHSYGGQVISTAAN------------------------------- 100
gi 145235011  65 REi---------------NQLv-eQGKEV---VVLAHSYGGMPASQSIQglvk--------------------------- 98
gi 738419039 115 GDraelta-----sareaGFTg-eLPTRV---VLAGHSAGGGLVVGTARymv---------------------------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74691106  167 -----------------------grfdgqgllkrcseNNp--NWIEKGGFYAT--T---------LR-QGkLQ--KIWIp 207
gi 499849571 147 -------------------------------------TErrvRRAAALITSGV--W---------EE-PE-VQ--KPELr 174
gi 506276259 114 -------------------------------ialnppRIp--ERRTRVLGIGArpHrg-----aePLaVDyRS--SSRA- 152
gi 506375408 131 vlknpsnrhkavgftheqwhyaftntfseadsramyeRYh--VPASGAIFWDS--V---------LA-NVtPG--HQETw 194
gi 501372783 110 -------------------------------------VD---SHVMGLVYVAA--HapnvgedeaTLgKGkPS--NTSK- 144
gi 750256997 109 -------------------------------------MD---PSVAGLVFIAA--Hm--------PDaGEnEA--DDGKr 136
gi 806926426 103 -------------------------------------VH---PSVVGLVYVAA--Ha--------PDvGEdES--ALGK- 129
gi 501553767 101 -------------------------------------GH---DNVKSLVYVAA--Fa--------PDaGEsVA--DLAGk 128
gi 145235011  99 ---------------------------------regsEHa--GGVVQLAYMTA--Vv-------pPEgK---S--SVDVl 129
gi 738419039 158 -----------------------------------enGDg--DDLAGVVMLDGagIi-------gVL-SAdLAkiPQSI- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74691106  208 keesfsvirtntlnyrnlshdtTVISIYGTNDEVV----PpmEASL---------------------------------- 249
gi 499849571 175 afleanrpv----thagdapptPLLLASGDHDPVF----SldEHHAptaa------------------------------ 216
gi 506276259 153 ----------------------PLLLVGGGVDRRV----PseSVEA---------------------------------- 172
gi 506375408 195 vdyh-------------ndarpPLLFISGGEDNLM----PpsVQRS---------------------------------- 223
gi 501372783 145 ----------------------QPGAIEKTNDGYTy--lNpsAFPKdfaadlp--------------------------- 173
gi 750256997 137 fps----------------dvsKSAAIKKTADGFTy--iDpsQFHEyfaadlsaeqaafmarsqvlnladnfna-vittp 197
gi 806926426 130 ----------------------KTPSVLGKTEGVIk--vTpdKFTYldpvqfpklfa----------------------- 162
gi 501553767 129 fpggtl----------gaalaaPVKLSGGGVDLYI----DqaKFHDqfasdvpaeqaalmaaaqrpvtdaalneksgepa 194
gi 145235011 130 a-------------------ngPSMDISVDEKGWMslvdTaaVAAA---------------------------------- 156
gi 738419039 192 ----------------------PVYNLAATPDSWN----NngHASQ---------------------------------- 211
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74691106  250 -----------------------DYSSVFk--DHH--QL----------------------------------------- 261
gi 499849571 217 -------------------ayrtAYAQAG---CPE--RFh---------------------------------------- 232
gi 506276259 173 -----------------------TARRYWkseAVT--SY----------------------------------------- 186
gi 506375408 224 -----------------------NAKHYK---SNTitEV----------------------------------------- 236
gi 501372783 174 ----------------lkqaqfeAHSQMP---TAA--KVfsqplkaaawttkpswgivagsdeiinpdlerwyyerahsh 232
gi 750256997 198 awrskptwvavagkdrminpdleRWYATR---ANS--HK----------------------------------------- 231
gi 806926426 163 ------------pdlpreraefvARSQVP---AAA--QVfstpltaaawktkpswgivagndqiinpdlerwyyeraksq 225
gi 501553767 195 wkklpswfvygtgdknipaaalaFMAERA---GSK--RT----------------------------------------- 228
gi 145235011 157 -----------------------AFSDVP---PDE--GM----------------------------------------- 167
gi 738419039 212 -----------------------RLKQAR---PDM--FTg---------------------------------------- 223
                        410
                 ....*....|
gi 74691106  262 -IYIDGAGHN 270
gi 499849571 233 eRVFPGVGHF 242
gi 506276259 187 -LEYPEGCHH 195
gi 506375408 237 -KEFEGFAHL 245
gi 501372783 233 tTVIPGASHS 242
gi 750256997 232 -VEVPGASHS 240
gi 806926426 226 tTVIPGASHS 235
gi 501553767 229 -VVVEGASHV 237
gi 145235011 168 -TWAQQFTHH 176
gi 738419039 224 -VLVQGGHHS 232
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