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SERHL2 serine hydrolase like 2 [ Homo sapiens (human) ]

Gene ID: 253190, updated on 9-Feb-2020

Summary

Official Symbol
SERHL2provided by HGNC
Official Full Name
serine hydrolase like 2provided by HGNC
Primary source
HGNC:HGNC:29446
See related
Ensembl:ENSG00000183569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ222E13.1
Expression
Ubiquitous expression in prostate (RPKM 8.8), ovary (RPKM 8.8) and 24 other tissues See more
Orthologs

Genomic context

See SERHL2 in Genome Data Viewer
Location:
22q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (42553850..42574382)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42949858..42970703)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene serine hydrolase like (pseudogene) Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene Sharpr-MPRA regulatory region 9885 Neighboring gene RN7SK pseudogene 80 Neighboring gene RNA, U6 small nuclear 513, pseudogene Neighboring gene ribosomal RNA processing 7 homolog B, pseudogene Neighboring gene DNA polymerase delta interacting protein 3 Neighboring gene RNA, U12 small nuclear

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149508, MGC157667, MGC157668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine hydrolase-like protein 2
Names
testis secretory sperm-binding protein Li 216e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284334.2NP_001271263.1  serine hydrolase-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001271263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL590118, AW134760, DC315058
    Consensus CDS
    CCDS63498.1
    UniProtKB/Swiss-Prot
    Q9H4I8
    Related
    ENSP00000336578.5, ENST00000335879.5
    Conserved Domains (1) summary
    COG0596
    Location:6241
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
  2. NM_014509.5NP_055324.2  serine hydrolase-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_055324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL450314, AW134760
    Consensus CDS
    CCDS14037.1
    UniProtKB/Swiss-Prot
    Q9H4I8
    UniProtKB/TrEMBL
    A0A140VK89
    Related
    ENSP00000331376.5, ENST00000327678.10
    Conserved Domains (1) summary
    COG0596
    Location:21305
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. NR_104300.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in both the 5' and 3' regions, and lacks an exon in the central region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294584, AL450314, AW134760
  2. NR_104301.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the central region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294584, AW134760, BC041802, DC315058
    Related
    ENST00000477564.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    42553850..42574382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028739.2XP_016884228.1  serine hydrolase-like protein 2 isoform X2

  2. XM_024452197.1XP_024307965.1  serine hydrolase-like protein 2 isoform X3

    Conserved Domains (1) summary
    cl27754
    Location:2291
    FabI; Enoyl-[acyl-carrier-protein] reductase (NADH) [Lipid transport and metabolism]
  3. XM_024452196.1XP_024307964.1  serine hydrolase-like protein 2 isoform X1

    Conserved Domains (1) summary
    COG0596
    Location:21332
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. XR_244363.3 RNA Sequence

    Related
    ENST00000340239.8
  2. XR_001755198.2 RNA Sequence

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