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SURF4 surfeit 4 [ Homo sapiens (human) ]

Gene ID: 6836, updated on 29-Mar-2023

Summary

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Official Symbol
SURF4provided by HGNC
Official Full Name
surfeit 4provided by HGNC
Primary source
HGNC:HGNC:11476
See related
Ensembl:ENSG00000148248 MIM:185660; AllianceGenome:HGNC:11476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERV29
Summary
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in duodenum (RPKM 40.0), small intestine (RPKM 39.7) and 25 other tissues See more
Orthologs
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Genomic context

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See SURF4 in Genome Data Viewer
Location:
9q34.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133361464..133377949, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145575418..145591909, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136228340..136244820, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SURF1 cytochrome c oxidase assembly factor Neighboring gene surfeit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136234564-136235235 Neighboring gene serine/threonine kinase like domain containing 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136257045-136257682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136265498-136266135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Surf4, cargo trafficking, lipid metabolism, and therapeutic implications. Shen Y, et al. J Mol Cell Biol, 2023 Feb 7. PMID 36574593, Free PMC Article
  2. High SURF4 expression is associated with poor prognosis of breast cancer. Zhai J, et al. Aging (Albany NY), 2022 Nov 29. PMID 36446386, Free PMC Article
  3. Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4. Tang X, et al. J Biol Chem, 2022 Dec. PMID 36370847, Free PMC Article
  4. SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. Yan R, et al. Dev Cell, 2022 Feb 28. PMID 35051356, Free PMC Article
  5. The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. Lin Z, et al. Mol Cell Biol, 2020 Nov 6. PMID 32989016, Free PMC Article

See all (114) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surf4, cargo trafficking, lipid metabolism, and therapeutic implications.
    Title: Surf4, cargo trafficking, lipid metabolism, and therapeutic implications.
  2. Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.
    Title: Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.
  3. High SURF4 expression is associated with poor prognosis of breast cancer.
    Title: High SURF4 expression is associated with poor prognosis of breast cancer.
  4. Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.
    Title: Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.
  5. A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.
    Title: A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.
  6. SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.
    Title: SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.
  7. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.
    Title: Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.
  8. Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
    Title: Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
  9. SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.
    Title: SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.
  10. The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion.
    Title: The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with surfeit 4 (SURF4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22993, MGC102753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cargo receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of organelle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in transport vesicle TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
surfeit locus protein 4
Names
surface 4 integral membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280788.2 → NP_001267717.1  surfeit locus protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL593848, BM557312, BX647961
    Conserved Domains (1) summary
    pfam02077
    Location:2 → 254
    SURF4; SURF4 family

  2. NM_001280789.2 → NP_001267718.1  surfeit locus protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001267718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF078867, BX647961, DC424374
    Consensus CDS
    CCDS65178.1
    UniProtKB/Swiss-Prot
    O15260
    Related
    ENSP00000419853.2, ENST00000485435.6
    Conserved Domains (1) summary
    cl21527
    Location:4 → 157
    DoxX; DoxX

  3. NM_001280790.2 → NP_001267719.1  surfeit locus protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001267719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK295435, BX647961
    Consensus CDS
    CCDS75929.1
    UniProtKB/TrEMBL
    B7Z1G8
    Related
    ENSP00000483216.1, ENST00000618229.4
    Conserved Domains (1) summary
    cl21527
    Location:1 → 226
    DoxX; DoxX

  4. NM_001280791.2 → NP_001267720.1  surfeit locus protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001267720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK316480, BX647961
    Consensus CDS
    CCDS75929.1
    UniProtKB/TrEMBL
    B7Z1G8
    Related
    ENSP00000481666.1, ENST00000613129.4
    Conserved Domains (1) summary
    cl21527
    Location:1 → 226
    DoxX; DoxX

  5. NM_001280792.2 → NP_001267721.1  surfeit locus protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001267721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300004, BX647961, DC424374
    Consensus CDS
    CCDS65177.1
    UniProtKB/Swiss-Prot
    O15260
    Related
    ENSP00000446061.1, ENST00000545297.5
    Conserved Domains (1) summary
    cl21527
    Location:4 → 119
    DoxX; DoxX

  6. NM_001280793.2 → NP_001267722.1  surfeit locus protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001267722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BX647961, DA842525, DC424374
    Conserved Domains (1) summary
    cl21527
    Location:1 → 152
    DoxX; DoxX

  7. NM_033161.4 → NP_149351.1  surfeit locus protein 4 isoform 1

    See identical proteins and their annotated locations for NP_149351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC018741, BX647961, DC424374
    Consensus CDS
    CCDS6968.1
    UniProtKB/Swiss-Prot
    O15260, Q9UNZ1
    Related
    ENSP00000361057.3, ENST00000371989.8
    Conserved Domains (1) summary
    pfam02077
    Location:4 → 269
    SURF4; SURF4 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133361464..133377949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518944.3 → XP_011517246.1  surfeit locus protein 4 isoform X2

    See identical proteins and their annotated locations for XP_011517246.1

    UniProtKB/TrEMBL
    B7Z7A8
    Conserved Domains (1) summary
    pfam02077
    Location:4 → 260
    SURF4; SURF4 family

  2. XM_047423807.1 → XP_047279763.1  surfeit locus protein 4 isoform X2

    UniProtKB/TrEMBL
    B7Z7A8

  3. XM_047423808.1 → XP_047279764.1  surfeit locus protein 4 isoform X4

    UniProtKB/TrEMBL
    B7Z1G8

  4. XM_047423805.1 → XP_047279761.1  surfeit locus protein 4 isoform X1

  5. XM_047423804.1 → XP_047279760.1  surfeit locus protein 4 isoform X1

  6. XM_047423806.1 → XP_047279762.1  surfeit locus protein 4 isoform X2

    UniProtKB/TrEMBL
    B7Z7A8

  7. XM_047423803.1 → XP_047279759.1  surfeit locus protein 4 isoform X1

  8. XM_011518945.4 → XP_011517247.1  surfeit locus protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011517247.1

    Conserved Domains (1) summary
    cl21527
    Location:110 → 206
    DoxX; DoxX

  9. XM_047423802.1 → XP_047279758.1  surfeit locus protein 4 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p14 PATCHES

    Range
    187558..204043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331589.1 → XP_054187564.1  surfeit locus protein 4 isoform X2

  2. XM_054331588.1 → XP_054187563.1  surfeit locus protein 4 isoform X2

  3. XM_054331591.1 → XP_054187566.1  surfeit locus protein 4 isoform X4

  4. XM_054331587.1 → XP_054187562.1  surfeit locus protein 4 isoform X2

  5. XM_054331590.1 → XP_054187565.1  surfeit locus protein 4 isoform X3

  6. XM_054331586.1 → XP_054187561.1  surfeit locus protein 4 isoform X2

  7. XM_054331585.1 → XP_054187560.1  surfeit locus protein 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145575418..145591909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363649.1 → XP_054219624.1  surfeit locus protein 4 isoform X2

  2. XM_054363648.1 → XP_054219623.1  surfeit locus protein 4 isoform X2

  3. XM_054363651.1 → XP_054219626.1  surfeit locus protein 4 isoform X4

  4. XM_054363647.1 → XP_054219622.1  surfeit locus protein 4 isoform X2

  5. XM_054363650.1 → XP_054219625.1  surfeit locus protein 4 isoform X3

  6. XM_054363646.1 → XP_054219621.1  surfeit locus protein 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15260.3 GenPept UniProtKB/Swiss-Prot:O15260

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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