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SULT2B1 sulfotransferase family 2B member 1 [ Homo sapiens (human) ]

Gene ID: 6820, updated on 9-Dec-2018

Summary

Official Symbol
SULT2B1provided by HGNC
Official Full Name
sulfotransferase family 2B member 1provided by HGNC
Primary source
HGNC:HGNC:11459
See related
Ensembl:ENSG00000088002 MIM:604125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSST2; ARCI14
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues See more
Orthologs

Genomic context

See SULT2B1 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (48552172..48599427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49055429..49102684)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372430 Neighboring gene cytohesin 2 Neighboring gene lemur tyrosine kinase 3 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4 Neighboring gene ribosomal protein L18 Neighboring gene sphingosine kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 14
MedGen: C4539754 OMIM: 617571 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
NHGRI GWA Catalog

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
    Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
    Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
    Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
    Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alcohol sulfotransferase activity TAS
Traceable Author Statement
more info
 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleic acid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid sulfotransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
sulfate assimilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sulfotransferase family cytosolic 2B member 1
Names
ST2B1
alcohol sulfotransferase
hydroxysteroid sulfotransferase 2
hydroxysteroid sulfotransferase SULT2B1a
sulfotransferase 2B1
sulfotransferase family, cytosolic, 2B, member 1
NP_004596.2
NP_814444.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029063.1 RefSeqGene

    Range
    5001..52256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004605.2NP_004596.2  sulfotransferase family cytosolic 2B member 1 isoform a

    See identical proteins and their annotated locations for NP_004596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SULT2B1a, differs in the 5' UTR and in the coding region when compared to variant 2. The resulting protein (isoform a) has a shorter and distinct N-terminus compared to isoform b.
    Source sequence(s)
    U92314
    Consensus CDS
    CCDS12724.1
    UniProtKB/Swiss-Prot
    O00204
    Related
    ENSP00000312880.3, ENST00000323090.4
    Conserved Domains (1) summary
    pfam00685
    Location:45290
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_177973.1NP_814444.1  sulfotransferase family cytosolic 2B member 1 isoform b

    See identical proteins and their annotated locations for NP_814444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is also known as SULT2B1b. It is the predominant transcript and it encodes the longer protein (isoform b).
    Source sequence(s)
    U92315
    Consensus CDS
    CCDS12723.1
    UniProtKB/Swiss-Prot
    O00204
    Related
    ENSP00000201586.1, ENST00000201586.6
    Conserved Domains (1) summary
    pfam00685
    Location:60305
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    48552172..48599427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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