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Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 [ Mus musculus (house mouse) ]

Gene ID: 54200, updated on 8-Feb-2024

Summary

Official Symbol
Sult2b1provided by MGI
Official Full Name
sulfotransferase family, cytosolic, 2B, member 1provided by MGI
Primary source
MGI:MGI:1926342
See related
Ensembl:ENSMUSG00000003271 AllianceGenome:MGI:1926342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST2B1; SULT2B
Summary
Enables sulfotransferase activity. Acts upstream of or within sulfate assimilation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14. Orthologous to human SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 60.2), large intestine adult (RPKM 56.9) and 4 other tissues See more
Orthologs
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Genomic context

See Sult2b1 in Genome Data Viewer
Location:
7 B3; 7 29.47 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45379405..45409096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45729981..45759672, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene sphingosine kinase 2 Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52988906-52989102 Neighboring gene STARR-seq mESC enhancer starr_18855 Neighboring gene predicted gene, 31597 Neighboring gene predicted gene, 39009 Neighboring gene predicted gene 5897 Neighboring gene lemur tyrosine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sulfotransferase 2B1
Names
alcohol sulfotransferase
hydroxysteroid sulfotransferase 2
sulfotransferase 2B
NP_001347713.1
NP_059493.2
XP_006541061.1
XP_006541062.1
XP_030098652.1
XP_030098653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360784.1NP_001347713.1  sulfotransferase 2B1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167242, BM899747
    Consensus CDS
    CCDS90241.1
    UniProtKB/TrEMBL
    A0A1B0GR49, A0A1B0GST5
    Related
    ENSMUSP00000148064.2, ENSMUST00000210754.2
    Conserved Domains (1) summary
    pfam00685
    Location:91334
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_017465.3NP_059493.2  sulfotransferase 2B1 isoform 1

    See identical proteins and their annotated locations for NP_059493.2

    Status: VALIDATED

    Source sequence(s)
    AC167242, AI851328, BM899747, CJ043038, CJ048619, CJ054084
    Consensus CDS
    CCDS21263.1
    UniProtKB/Swiss-Prot
    O35400, Q8K472, Q91V03
    UniProtKB/TrEMBL
    A0A1B0GR49
    Related
    ENSMUSP00000075005.8, ENSMUST00000075571.16
    Conserved Domains (1) summary
    pfam00685
    Location:57300
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45379405..45409096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242793.1XP_030098653.1  sulfotransferase 2B1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GR49
    Conserved Domains (1) summary
    pfam00685
    Location:18261
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_030242792.1XP_030098652.1  sulfotransferase 2B1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GR49
    Conserved Domains (1) summary
    pfam00685
    Location:18261
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_006540999.2XP_006541062.1  sulfotransferase 2B1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GR49
    Related
    ENSMUSP00000147374.2, ENSMUST00000209739.2
    Conserved Domains (1) summary
    pfam00685
    Location:18261
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_006540998.3XP_006541061.1  sulfotransferase 2B1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GR49
    Conserved Domains (1) summary
    pfam00685
    Location:53296
    Sulfotransfer_1; Sulfotransferase domain