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Rnf146 ring finger protein 146 [ Mus musculus (house mouse) ]

Gene ID: 68031, updated on 8-Feb-2024

Summary

Official Symbol
Rnf146provided by MGI
Official Full Name
ring finger protein 146provided by MGI
Primary source
MGI:MGI:1915281
See related
Ensembl:ENSMUSG00000038876 AllianceGenome:MGI:1915281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iduna; 2610509H23Rik
Summary
Predicted to enable poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of hydrogen peroxide-induced cell death; positive regulation of canonical Wnt signaling pathway; and protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Used to study cleidocranial dysplasia. Orthologous to human RNF146 (ring finger protein 146). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 13.4), CNS E14 (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf146 in Genome Data Viewer
Location:
10 A4; 10 16.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (29220172..29238438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (29344176..29362442, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene MTCL family member 3 Neighboring gene RIKEN cDNA 9330159F19 gene Neighboring gene STARR-seq mESC enhancer starr_26176 Neighboring gene predicted gene, 46218 Neighboring gene STARR-seq mESC enhancer starr_26177 Neighboring gene enoyl Coenzyme A hydratase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6827 Neighboring gene predicted gene, 25596 Neighboring gene predicted gene, 30698 Neighboring gene predicted gene, 40621 Neighboring gene predicted gene, 24286

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly-ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF146
Names
RING-type E3 ubiquitin transferase RNF146
NP_001103666.1
NP_001103667.1
NP_001103668.1
NP_001271208.1
NP_080794.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110196.1NP_001103666.1  E3 ubiquitin-protein ligase RNF146

    See identical proteins and their annotated locations for NP_001103666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK012080, AK035665, BC050795, BF461810, BQ713250
    Consensus CDS
    CCDS48529.1
    UniProtKB/Swiss-Prot
    E0CX97, Q3TF93, Q3U6Y7, Q9CZW6
    Related
    ENSMUSP00000124215.2, ENSMUST00000160372.9
    Conserved Domains (2) summary
    smart00678
    Location:105177
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:3779
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_001110197.1NP_001103667.1  E3 ubiquitin-protein ligase RNF146

    See identical proteins and their annotated locations for NP_001103667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK035665, BC050795, BF461810, BQ713250, BY787516
    Consensus CDS
    CCDS48529.1
    UniProtKB/Swiss-Prot
    E0CX97, Q3TF93, Q3U6Y7, Q9CZW6
    Related
    ENSMUSP00000037224.5, ENSMUST00000037548.11
    Conserved Domains (2) summary
    smart00678
    Location:105177
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:3779
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001110198.1NP_001103668.1  E3 ubiquitin-protein ligase RNF146

    See identical proteins and their annotated locations for NP_001103668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK035665, BC050795, BF461810, BQ713250, BU562186
    Consensus CDS
    CCDS48529.1
    UniProtKB/Swiss-Prot
    E0CX97, Q3TF93, Q3U6Y7, Q9CZW6
    Conserved Domains (2) summary
    smart00678
    Location:105177
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:3779
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. NM_001284279.1NP_001271208.1  E3 ubiquitin-protein ligase RNF146

    See identical proteins and their annotated locations for NP_001271208.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC153912, AK012080, AK016748, BF461810
    Consensus CDS
    CCDS48529.1
    UniProtKB/Swiss-Prot
    E0CX97, Q3TF93, Q3U6Y7, Q9CZW6
    Related
    ENSMUSP00000124772.2, ENSMUST00000162335.8
    Conserved Domains (2) summary
    smart00678
    Location:105177
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:3779
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. NM_026518.4NP_080794.2  E3 ubiquitin-protein ligase RNF146

    See identical proteins and their annotated locations for NP_080794.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site and also lacks an exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK035665, BC050795, BF461810, BQ713250
    Consensus CDS
    CCDS48529.1
    UniProtKB/Swiss-Prot
    E0CX97, Q3TF93, Q3U6Y7, Q9CZW6
    Related
    ENSMUSP00000124288.2, ENSMUST00000160144.9
    Conserved Domains (2) summary
    smart00678
    Location:105177
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:3779
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    29220172..29238438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)