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RNF146 ring finger protein 146 [ Homo sapiens (human) ]

Gene ID: 81847, updated on 12-Oct-2019

Summary

Official Symbol
RNF146provided by HGNC
Official Full Name
ring finger protein 146provided by HGNC
Primary source
HGNC:HGNC:21336
See related
Ensembl:ENSG00000118518 MIM:612137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See RNF146 in Genome Data Viewer
Location:
6q22.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (127263415..127289893)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127587827..127609707)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377989 Neighboring gene R-spondin 3 Neighboring gene uncharacterized LOC112267972 Neighboring gene uncharacterized LOC105377994 Neighboring gene ethylmalonyl-CoA decarboxylase 1 Neighboring gene RNA, 5S ribosomal pseudogene 217

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at 6q22 and 17q21 are associated with intracranial volume.
NHGRI GWA Catalog
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
NHGRI GWA Catalog

Pathways from BioSystems

  • Degradation of AXIN, organism-specific biosystem (from REACTOME)
    Degradation of AXIN, organism-specific biosystemAXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, howev...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • dJ351K20.1, 2610509H23Rik, DKFZp434O1427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly-ADP-D-ribose binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF146
Names
RING-type E3 ubiquitin transferase RNF146
dactylidin
iduna
NP_001229773.1
NP_001229774.1
NP_001229775.1
NP_001229776.1
NP_001229777.1
NP_001229778.1
NP_001229779.1
NP_001229780.1
NP_001229781.1
NP_112225.2
XP_006715634.1
XP_011534463.1
XP_011534464.1
XP_011534465.1
XP_011534466.1
XP_016866825.1
XP_016866827.1
XP_016866828.1
XP_016866829.1
XP_016866830.1
XP_016866831.1
XP_016866832.1
XP_024302331.1
XP_024302332.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242844.1NP_001229773.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI929027, AJ420549, DA639989
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  2. NM_001242845.1NP_001229774.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, BI669435, DA707096, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  3. NM_001242846.1NP_001229775.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA043259, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000477168.1, ENST00000608991.5
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  4. NM_001242847.1NP_001229776.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI929027, AJ420549, DA707096
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  5. NM_001242848.1NP_001229777.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA145911, DB267873
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  6. NM_001242849.1NP_001229778.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AI929027, AJ420549, CN388414
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000476814.1, ENST00000610153.1
    Conserved Domains (2) summary
    smart00678
    Location:104176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3675
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  7. NM_001242850.1NP_001229779.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AJ420549, AK027558, DB267873
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000357297.1, ENST00000368314.5
    Conserved Domains (2) summary
    smart00678
    Location:104176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3675
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  8. NM_001242851.1NP_001229780.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate 5' terminal exon and lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AJ420549, BG708628, BI771613
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000479890.1, ENST00000616343.4
    Conserved Domains (2) summary
    smart00678
    Location:104176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3675
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  9. NM_001242852.1NP_001229781.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-4 and variant 7 encode the same isoform.
    Source sequence(s)
    AI929027, AJ420549, AL136829, DA826982
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000309365.3, ENST00000309649.7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  10. NM_030963.3NP_112225.2  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_112225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, AL136829, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    127263415..127289893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011339.2XP_016866828.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  2. XM_017011340.2XP_016866829.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  3. XM_017011343.2XP_016866832.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  4. XM_017011342.2XP_016866831.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  5. XM_017011341.2XP_016866830.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  6. XM_017011336.2XP_016866825.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:104176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3675
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  7. XM_017011338.2XP_016866827.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  8. XM_011536161.3XP_011534463.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    See identical proteins and their annotated locations for XP_011534463.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  9. XM_011536163.3XP_011534465.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    See identical proteins and their annotated locations for XP_011534465.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  10. XM_011536164.3XP_011534466.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    See identical proteins and their annotated locations for XP_011534466.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  11. XM_011536162.3XP_011534464.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    See identical proteins and their annotated locations for XP_011534464.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  12. XM_006715571.4XP_006715634.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    See identical proteins and their annotated locations for XP_006715634.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  13. XM_024446563.1XP_024302331.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
  14. XM_024446564.1XP_024302332.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    Conserved Domains (2) summary
    smart00678
    Location:103175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:3574
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
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