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Pold3 polymerase (DNA-directed), delta 3, accessory subunit [ Mus musculus (house mouse) ]

Gene ID: 67967, updated on 2-Nov-2024

Summary

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Official Symbol
Pold3provided by MGI
Official Full Name
polymerase (DNA-directed), delta 3, accessory subunitprovided by MGI
Primary source
MGI:MGI:1915217
See related
Ensembl:ENSMUSG00000030726 AllianceGenome:MGI:1915217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P66; P68; 2410142G14Rik
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human POLD3 (DNA polymerase delta 3, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.4), liver E14 (RPKM 17.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pold3 in Genome Data Viewer
Location:
7 E2; 7 54.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99731317..99770709, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100082110..100121502, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene chordin-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E3737 Neighboring gene predicted gene, 34760 Neighboring gene STARR-positive B cell enhancer ABC_E11740 Neighboring gene predicted gene, 51452 Neighboring gene lipoyl(octanoyl) transferase 2 (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNA polymerase delta is involved in the cellular response to UV damage in human cells. Zeng XR, et al. J Biol Chem, 1994 May 13. PMID 7910606
  2. DNA polymerase delta is required for human mismatch repair in vitro. Longley MJ, et al. J Biol Chem, 1997 Apr 18. PMID 9099749
  3. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Hughes P, et al. Nucleic Acids Res, 1999 May 15. PMID 10219083, Free PMC Article
  4. POLD3 Is Haploinsufficient for DNA Replication in Mice. Murga M, et al. Mol Cell, 2016 Sep 1. PMID 27524497, Free PMC Article
  5. Expression of testicular germ cell genes identified by differential display analysis. Anway MD, et al. J Androl, 2003 Mar-Apr. PMID 12634303

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA synthesis involved in UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA gap filling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase delta subunit 3
Names
DNA polymerase delta subunit p66
GC12
polymerase (DNA directed), delta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368380.1 → NP_001355309.1  DNA polymerase delta subunit 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161205
    UniProtKB/Swiss-Prot
    Q9EQ28
    UniProtKB/TrEMBL
    Q3THQ7

  2. NM_133692.2 → NP_598453.1  DNA polymerase delta subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_598453.1

    Status: VALIDATED

    Source sequence(s)
    AK031778
    Consensus CDS
    CCDS21493.1
    UniProtKB/TrEMBL
    Q3THQ7, Q8BH76
    Related
    ENSMUSP00000032969.8, ENSMUST00000032969.14
    Conserved Domains (2) summary
    pfam09507
    Location:19 → 461
    CDC27; DNA polymerase subunit Cdc27
    cl04813
    Location:243 → 340
    EIN3; Ethylene insensitive 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99731317..99770709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242944.2 → XP_030098804.1  DNA polymerase delta subunit 3 isoform X3

    UniProtKB/TrEMBL
    Q3TS65
    Conserved Domains (1) summary
    pfam09507
    Location:6 → 272
    CDC27; DNA polymerase subunit Cdc27

  2. XM_006508150.5 → XP_006508213.1  DNA polymerase delta subunit 3 isoform X1

    UniProtKB/TrEMBL
    Q3THQ7
    Conserved Domains (1) summary
    pfam09507
    Location:1 → 423
    CDC27; DNA polymerase subunit Cdc27

  3. XM_030242943.2 → XP_030098803.1  DNA polymerase delta subunit 3 isoform X2

    UniProtKB/TrEMBL
    A0A140LHY7, Q3THQ7
    Related
    ENSMUSP00000146603.2, ENSMUST00000208670.2
    Conserved Domains (1) summary
    pfam09507
    Location:1 → 422
    CDC27; DNA polymerase subunit Cdc27
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ28.2 GenPept UniProtKB/Swiss-Prot:Q9EQ28

Gene LinkOut

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