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POLD3 DNA polymerase delta 3, accessory subunit [ Homo sapiens (human) ]

Gene ID: 10714, updated on 1-Jun-2020

Summary

Official Symbol
POLD3provided by HGNC
Official Full Name
DNA polymerase delta 3, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:20932
See related
Ensembl:ENSG00000077514 MIM:611415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P66; P68; PPP1R128
Summary
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in testis (RPKM 7.5), colon (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See POLD3 in Genome Data Viewer
Location:
11q13.4
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74592582..74669341)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74303575..74380386)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287896 Neighboring gene lipoyl(octanoyl) transferase 2 Neighboring gene uncharacterized LOC105369386 Neighboring gene RAN pseudogene 3 Neighboring gene RN7SK pseudogene 297 Neighboring gene chordin like 2 Neighboring gene microRNA 4696

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0039, MGC119642, MGC119643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA synthesis involved in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
DNA synthesis involved in UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair NAS
Non-traceable Author Statement
more info
PubMed 
mismatch repair TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-excision repair, DNA gap filling IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
telomere maintenance TAS
Traceable Author Statement
more info
 
telomere maintenance via semi-conservative replication TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
zeta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase delta subunit 3
Names
DNA polymerase delta subunit C
DNA polymerase delta subunit p66
DNA polymerase delta subunit p68
Pol delta C subunit (p66)
polymerase (DNA) delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
protein phosphatase 1, regulatory subunit 128

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363597.2NP_001350526.1  DNA polymerase delta subunit 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP001104, AP001324
    Consensus CDS
    CCDS86228.1
    Related
    ENSP00000432951.1, ENST00000527458.5
    Conserved Domains (1) summary
    pfam09507
    Location:1427
    CDC27; DNA polymerase subunit Cdc27
  2. NM_006591.3NP_006582.1  DNA polymerase delta subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_006582.1

    Status: REVIEWED

    Source sequence(s)
    AK316301, AP001324, D26018, DC402448
    Consensus CDS
    CCDS8233.1
    UniProtKB/Swiss-Prot
    Q15054
    UniProtKB/TrEMBL
    A0A024R5M8
    Related
    ENSP00000263681.2, ENST00000263681.7
    Conserved Domains (1) summary
    pfam09507
    Location:19466
    CDC27; DNA polymerase subunit Cdc27

RNA

  1. NR_046409.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001324, BC108908, DC402448
  2. NR_046410.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK302677, AP001104, AP001324, BC108909

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74592582..74669341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273716.1XP_005273773.1  DNA polymerase delta subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam09507
    Location:19400
    CDC27; DNA polymerase subunit Cdc27
  2. XM_011544734.3XP_011543036.1  DNA polymerase delta subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam09507
    Location:3448
    CDC27; DNA polymerase subunit Cdc27
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