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AURKA aurora kinase A [ Homo sapiens (human) ]

Gene ID: 6790, updated on 2-Aug-2021

Summary

Official Symbol
AURKAprovided by HGNC
Official Full Name
aurora kinase Aprovided by HGNC
Primary source
HGNC:HGNC:11393
See related
Ensembl:ENSG00000087586 MIM:603072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47
Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 12.9), lymph node (RPKM 6.9) and 16 other tissues See more
Orthologs
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Genomic context

See AURKA in Genome Data Viewer
Location:
20q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (56369390..56392308, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (54944446..54967271, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene melanocortin 3 receptor Neighboring gene family with sequence similarity 210 member B Neighboring gene cleavage stimulation factor subunit 1 Neighboring gene Cas scaffold protein family member 4 Neighboring gene ribosomal protein L39 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates AURKA in HeLa cells within 12 hours of exposure PubMed
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein aurora kinase A (AURKA, AURA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34538

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
involved_in anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome localization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within liver regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic centrosome separation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
involved_in regulation of centrosome cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle assembly involved in female meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon hillock IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome TAS
Traceable Author Statement
more info
PubMed 
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in germinal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody TAS
Traceable Author Statement
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in pronucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aurora kinase A
Names
aurora 2
aurora/IPL1-like kinase
aurora/IPL1-related kinase 1
breast tumor-amplified kinase
protein phosphatase 1, regulatory subunit 47
serine/threonine protein kinase 15
serine/threonine-protein kinase 6
serine/threonine-protein kinase aurora-A
NP_001310232.1
NP_001310233.1
NP_001310234.1
NP_003591.2
NP_940835.1
NP_940836.1
NP_940837.1
NP_940838.1
NP_940839.1
XP_016883523.1
XP_016883524.1
XP_024307742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012133.1 RefSeqGene

    Range
    5081..27906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001323303.2NP_001310232.1  aurora kinase A

    Status: REVIEWED

    Source sequence(s)
    AF011468, AL121914, BP224535
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  2. NM_001323304.2NP_001310233.1  aurora kinase A

    Status: REVIEWED

    Source sequence(s)
    BC001280, BP224535, BU171303
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000360407.2, ENST00000371356.6
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  3. NM_001323305.2NP_001310234.1  aurora kinase A

    Status: REVIEWED

    Source sequence(s)
    AF011468, AL121914
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  4. NM_003600.4NP_003591.2  aurora kinase A

    See identical proteins and their annotated locations for NP_003591.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, AL711075, BP224535
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000216911.2, ENST00000347343.6
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  5. NM_198433.3NP_940835.1  aurora kinase A

    See identical proteins and their annotated locations for NP_940835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-9 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, AL711075, BC027464, BP224535, BU542363
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  6. NM_198434.3NP_940836.1  aurora kinase A

    See identical proteins and their annotated locations for NP_940836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, BM458030, BP224535
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379250.1, ENST00000395914.5
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  7. NM_198435.3NP_940837.1  aurora kinase A

    See identical proteins and their annotated locations for NP_940837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AF011468, BU171303
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379249.3, ENST00000395913.7
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  8. NM_198436.3NP_940838.1  aurora kinase A

    See identical proteins and their annotated locations for NP_940838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF011468, BQ435059, CB113289
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000321591.6, ENST00000312783.10
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  9. NM_198437.3NP_940839.1  aurora kinase A

    See identical proteins and their annotated locations for NP_940839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, BF029182, BP224535
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379251.3, ENST00000395915.8
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    56369390..56392308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028034.2XP_016883523.1  aurora kinase A isoform X1

  2. XM_024451974.1XP_024307742.1  aurora kinase A isoform X2

    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
  3. XM_017028035.1XP_016883524.1  aurora kinase A isoform X2

    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (1) summary
    cd14116
    Location:127384
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
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