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Aurka aurora kinase A [ Mus musculus (house mouse) ]

Gene ID: 20878, updated on 22-Jan-2023

Summary

Official Symbol
Aurkaprovided by MGI
Official Full Name
aurora kinase Aprovided by MGI
Primary source
MGI:MGI:894678
See related
Ensembl:ENSMUSG00000027496 AllianceGenome:MGI:894678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A
Summary
Enables histone serine kinase activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including microtubule cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues See more
Orthologs
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Genomic context

See Aurka in Genome Data Viewer
Location:
2 H3; 2 94.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172198110..172212820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172356190..172370886, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14273 Neighboring gene family with sequence similarity 210, member B Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene uncharacterized LOC118568483 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone serine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centrosome cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver regeneration ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic centrosome separation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of spindle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in germinal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aurora kinase A
Names
aurora 2
aurora A
aurora family kinase 1
aurora-related kinase 1
aurora/IPL1-related kinase 1
ipl1- and aurora-related kinase 1
serine/threonine kinase 6
serine/threonine-protein kinase 15
serine/threonine-protein kinase 6
serine/threonine-protein kinase Ayk1
serine/threonine-protein kinase aurora-A
NP_001278114.1
NP_035627.1
XP_006499138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291185.1NP_001278114.1  aurora kinase A isoform b

    See identical proteins and their annotated locations for NP_001278114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK145968, AL833787, AL844162
    Consensus CDS
    CCDS71204.1
    UniProtKB/Swiss-Prot
    P97477, Q91YU4
    UniProtKB/TrEMBL
    Q3TEY6
    Related
    ENSMUSP00000104768.4, ENSMUST00000109140.10
    Conserved Domains (1) summary
    cl21453
    Location:118374
    PKc_like; Protein Kinases, catalytic domain
  2. NM_011497.4NP_035627.1  aurora kinase A isoform a

    See identical proteins and their annotated locations for NP_035627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK145968, AL833787, AL844162, CD560646
    Consensus CDS
    CCDS17129.1
    UniProtKB/Swiss-Prot
    P97477
    UniProtKB/TrEMBL
    A0A8C6I5X8, Q3TEY6
    Related
    ENSMUSP00000028997.8, ENSMUST00000028997.8
    Conserved Domains (2) summary
    smart00220
    Location:146396
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14116
    Location:140396
    STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172198110..172212820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499075.4XP_006499138.1  aurora kinase A isoform X1

    See identical proteins and their annotated locations for XP_006499138.1

    UniProtKB/Swiss-Prot
    P97477, Q91YU4
    UniProtKB/TrEMBL
    Q3TEY6
    Conserved Domains (1) summary
    cl21453
    Location:118374
    PKc_like; Protein Kinases, catalytic domain