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Ddx55 DEAD box helicase 55 [ Mus musculus (house mouse) ]

Gene ID: 67848, updated on 5-Mar-2024

Summary

Official Symbol
Ddx55provided by MGI
Official Full Name
DEAD box helicase 55provided by MGI
Primary source
MGI:MGI:1915098
See related
Ensembl:ENSMUSG00000029389 AllianceGenome:MGI:1915098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1595; 2810021H22Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX55 (DEAD-box helicase 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.5), CNS E18 (RPKM 5.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 63.66 cM; 5 F
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124690895..124707723)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124552832..124569660)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene eukaryotic translation initiation factor 2B, subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene general transcription factor IIH, polypeptide 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC143677, MGC143678

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX55
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
DEAD box protein 55
NP_001177724.1
NP_080685.2
XP_036021336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190795.1NP_001177724.1  ATP-dependent RNA helicase DDX55 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC043052, BY202366
    Consensus CDS
    CCDS57380.1
    UniProtKB/TrEMBL
    E9Q9T6, Q810A4
    Related
    ENSMUSP00000107065.2, ENSMUST00000111438.2
    Conserved Domains (4) summary
    COG0513
    Location:2513
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00268
    Location:9224
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:252363
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:399458
    DUF4217; Domain of unknown function (DUF4217)
  2. NM_026409.4NP_080685.2  ATP-dependent RNA helicase DDX55 isoform 1

    See identical proteins and their annotated locations for NP_080685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033741, BC043052, BY202366
    Consensus CDS
    CCDS39281.1
    UniProtKB/Swiss-Prot
    Q149H5, Q3U460, Q6ZPL9, Q8BZR1
    UniProtKB/TrEMBL
    Q810A4
    Related
    ENSMUSP00000070279.8, ENSMUST00000071057.14
    Conserved Domains (4) summary
    smart00487
    Location:24228
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:9224
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:252363
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:403462
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124690895..124707723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165443.1XP_036021336.1  ATP-dependent RNA helicase DDX55 isoform X1

    Conserved Domains (2) summary
    COG0513
    Location:16231
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam13959
    Location:258315
    DUF4217; Domain of unknown function (DUF4217)

RNA

  1. XR_387576.4 RNA Sequence