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STAT5B signal transducer and activator of transcription 5B [ Homo sapiens (human) ]

Gene ID: 6777, updated on 3-Mar-2026
Official Symbol
STAT5Bprovided by HGNC
Official Full Name
signal transducer and activator of transcription 5Bprovided by HGNC
Primary source
HGNC:HGNC:11367
See related
Ensembl:ENSG00000173757 MIM:604260; AllianceGenome:HGNC:11367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAT5; GHISID2
Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 26.3), ovary (RPKM 25.7) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See STAT5B in Genome Data Viewer
Location:
17q21.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42199177..42288370, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43055661..43144521, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40351195..40428409, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40336245-40337046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40345000-40345530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12191 Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40439573-40440073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12193 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:40480835-40481564 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40481565-40482295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12197 Neighboring gene signal transducer and activator of transcription 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12200 Neighboring gene uncharacterized LOC102725238 Neighboring gene caveolae associated protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Nuclear expression of STAT5 in intraductal papillary mucinous neoplasms of the pancreas. Kataoka TR, et al. Int J Surg Pathol, 2007 Jul. PMID 17652536
  2. Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. Xiong H, et al. Lab Invest, 2009 Jun. PMID 19290007
  3. Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies. Mitra A, et al. J Biol Chem, 2012 May 11. PMID 22442148, Free PMC Article
  4. Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting. Koppikar P, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047094, Free PMC Article
  5. STAT5 contributes to antiapoptosis in melanoma. Hassel JC, et al. Melanoma Res, 2008 Dec. PMID 19011510

See all (328) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3-STAT5B interaction facilitates the co-transcriptional m[6]A modification of mRNA to promote breast tumorigenesis.
    Title: METTL3-STAT5B interaction facilitates the co-transcriptional m(6)A modification of mRNA to promote breast tumorigenesis.
  2. Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
    Title: Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
  3. PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry.
    Title: PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry.
  4. Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer.
    Title: Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer.
  5. STAT5b: A master regulator of key biological pathways.
    Title: STAT5b: A master regulator of key biological pathways.
  6. STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.
    Title: STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.
  7. Identification of novel STAT5B mutations and characterization of TCRbeta signatures in CD4+ T-cell large granular lymphocyte leukemia.
    Title: Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia.
  8. miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b.
    Title: miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b.
  9. Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings.
    Title: Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings.
  10. Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
    Title: Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
Submit: New GeneRIF Correction See all GeneRIFs (211)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CD4 ligation with HIV gp120 inhibits T cell receptor-induced tyrosine phosphorylation and expression of STAT5 by blocking activation and expression of JAK3 PubMed
capsid gag Silencing C-terminally truncated STAT5 expression by siRNA enhances HIV-1 RNA and p24 Gag expression in chronically HIV-infected U1 cell line PubMed
gag STAT5 binds to the HIV-1 LTR during HIV infection, activating LTR transcription and leading to the upregulation of HIV-1 p24 Capsid production and an increase in the number of p24+ cells PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that STAT5B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with STAT5B PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to hormone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in erythropoietin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect taurine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
signal transducer and activator of transcription 5B
Names
transcription factor STAT5B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007271.1 RefSeqGene

    Range
    5001..82230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_192

mRNA and Protein(s)

  1. NM_012448.4 → NP_036580.2  signal transducer and activator of transcription 5B

    See identical proteins and their annotated locations for NP_036580.2

    Status: REVIEWED

    Source sequence(s)
    BC065227, U47686
    Consensus CDS
    CCDS11423.1
    UniProtKB/Swiss-Prot
    P51692, Q8WWS8
    UniProtKB/TrEMBL
    A0A8V8TP16
    Related
    ENSP00000293328.3, ENST00000293328.8
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42199177..42288370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436593.1 → XP_047292549.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8V8TP16

  2. XM_024450897.2 → XP_024306665.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/Swiss-Prot
    P51692, Q8WWS8
    UniProtKB/TrEMBL
    A0A8V8TP16
    Related
    ENSP00000513923.1, ENST00000698776.1
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  3. XM_017024977.2 → XP_016880466.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8V8TP16
    Related
    ENST00000698801.1
    Conserved Domains (4) summary
    cd10420
    Location:479 → 623
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:47 → 236
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:238 → 488
    STAT_bind; STAT protein, DNA binding domain
    cl03749
    Location:2 → 31
    STAT_int; STAT protein, protein interaction domain

  4. XM_024450898.2 → XP_024306666.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/Swiss-Prot
    P51692, Q8WWS8
    UniProtKB/TrEMBL
    A0A8V8TP16
    Conserved Domains (4) summary
    cd10420
    Location:573 → 717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  5. XM_005257626.5 → XP_005257683.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8V8TM91
    Related
    ENSP00000513953.1, ENST00000698815.1
    Conserved Domains (3) summary
    smart00964
    Location:2 → 125
    STAT_int; STAT protein, protein interaction domain
    cd16855
    Location:139 → 330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332 → 489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43055661..43144521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316998.1 → XP_054172973.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/Swiss-Prot
    P51692, Q8WWS8
    UniProtKB/TrEMBL
    A0A8V8TP16

  2. XM_054317001.1 → XP_054172976.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8V8TP16

  3. XM_054317000.1 → XP_054172975.1  signal transducer and activator of transcription 5B isoform X2

    UniProtKB/TrEMBL
    A0A8V8TP16

  4. XM_054316999.1 → XP_054172974.1  signal transducer and activator of transcription 5B isoform X1

    UniProtKB/Swiss-Prot
    P51692, Q8WWS8
    UniProtKB/TrEMBL
    A0A8V8TP16

  5. XM_054317002.1 → XP_054172977.1  signal transducer and activator of transcription 5B isoform X3

    UniProtKB/TrEMBL
    A0A8V8TM91
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51692.2 GenPept UniProtKB/Swiss-Prot:P51692

Gene LinkOut

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