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STAT5B signal transducer and activator of transcription 5B [ Homo sapiens (human) ]

Gene ID: 6777, updated on 11-Oct-2020

Summary

Official Symbol
STAT5Bprovided by HGNC
Official Full Name
signal transducer and activator of transcription 5Bprovided by HGNC
Primary source
HGNC:HGNC:11367
See related
Ensembl:ENSG00000173757 MIM:604260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAT5; GHISID2
Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 26.3), ovary (RPKM 25.7) and 25 other tissues See more
Orthologs

Genomic context

See STAT5B in Genome Data Viewer
Location:
17q21.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42199177..42288437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40351195..40428478, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5A Neighboring gene signal transducer and activator of transcription 3 Neighboring gene uncharacterized LOC102725238 Neighboring gene caveolae associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
GROWTH HORMONE INSENSITIVITY SYNDROME WITH IMMUNE DYSREGULATION 2, AUTOSOMAL DOMINANT
MedGen: CN283329 OMIM: 618985 GeneReviews: Not available
not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Laron syndrome with immunodeficiency
MedGen: C1855548 OMIM: 245590 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CD4 ligation with HIV gp120 inhibits T cell receptor-induced tyrosine phosphorylation and expression of STAT5 by blocking activation and expression of JAK3 PubMed
capsid gag Silencing C-terminally truncated STAT5 expression by siRNA enhances HIV-1 RNA and p24 Gag expression in chronically HIV-infected U1 cell line PubMed
gag STAT5 binds to the HIV-1 LTR during HIV infection, activating LTR transcription and leading to the upregulation of HIV-1 p24 Capsid production and an increase in the number of p24+ cells PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that STAT5B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with STAT5B PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
Peyer's patch development IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
development of secondary female sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
development of secondary male sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-9-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
lipid storage IEA
Inferred from Electronic Annotation
more info
 
luteinization IEA
Inferred from Electronic Annotation
more info
 
mast cell migration IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
taurine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 5B
Names
transcription factor STAT5B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007271.1 RefSeqGene

    Range
    5001..82230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_192

mRNA and Protein(s)

  1. NM_012448.4NP_036580.2  signal transducer and activator of transcription 5B

    See identical proteins and their annotated locations for NP_036580.2

    Status: REVIEWED

    Source sequence(s)
    BC065227, U47686
    Consensus CDS
    CCDS11423.1
    UniProtKB/Swiss-Prot
    P51692
    Related
    ENSP00000293328.3, ENST00000293328.8
    Conserved Domains (4) summary
    cd10420
    Location:573717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42199177..42288437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450897.1XP_024306665.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2124
    STAT_int; STAT protein, protein interaction domain
  2. XM_017024977.1XP_016880466.1  signal transducer and activator of transcription 5B isoform X2

    Conserved Domains (4) summary
    cd10420
    Location:479623
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:47236
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:238488
    STAT_bind; STAT protein, DNA binding domain
    cl03749
    Location:231
    STAT_int; STAT protein, protein interaction domain
  3. XM_024450898.1XP_024306666.1  signal transducer and activator of transcription 5B isoform X1

    Conserved Domains (4) summary
    cd10420
    Location:573717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2124
    STAT_int; STAT protein, protein interaction domain
  4. XM_005257626.4XP_005257683.1  signal transducer and activator of transcription 5B isoform X3

    Conserved Domains (3) summary
    pfam01017
    Location:141330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332492
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2124
    STAT_int; STAT protein, protein interaction domain
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