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Ddx47 DEAD box helicase 47 [ Mus musculus (house mouse) ]

Gene ID: 67755, updated on 12-May-2024

Summary

Official Symbol
Ddx47provided by MGI
Official Full Name
DEAD box helicase 47provided by MGI
Primary source
MGI:MGI:1915005
See related
Ensembl:ENSMUSG00000030204 AllianceGenome:MGI:1915005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930588A18Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in RNA splicing; extrinsic apoptotic signaling pathway via death domain receptors; and rRNA processing. Predicted to act upstream of or within apoptotic process and mRNA processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human DDX47 (DEAD-box helicase 47). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 40.9), liver E14 (RPKM 29.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ddx47 in Genome Data Viewer
Location:
6 G1; 6 65.77 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134988575..135000739)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135011612..135023776)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:134897243-134897544 Neighboring gene lncRNA downstream of Cdkn1b Neighboring gene STARR-positive B cell enhancer mm9_chr6:134931598-134931898 Neighboring gene predicted gene, 36428 Neighboring gene apolipoprotein L domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E865 Neighboring gene STARR-seq mESC enhancer starr_17562 Neighboring gene G protein-coupled receptor, family C, group 5, member A Neighboring gene G protein-coupled receptor, family C, group 5, member D

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX47
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DEAD box protein 47
NP_080636.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026360.3NP_080636.2  probable ATP-dependent RNA helicase DDX47

    See identical proteins and their annotated locations for NP_080636.2

    Status: VALIDATED

    Source sequence(s)
    AK010310, BB682132, BY123864
    Consensus CDS
    CCDS20643.1
    UniProtKB/Swiss-Prot
    Q9CWX9
    UniProtKB/TrEMBL
    A0A0N4SVT1, Q4VBG1
    Related
    ENSMUSP00000032326.5, ENSMUST00000032326.11
    Conserved Domains (3) summary
    PRK11192
    Location:24446
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    cd00079
    Location:237366
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:26227
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    134988575..135000739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)