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SSTR2 somatostatin receptor 2 [ Homo sapiens (human) ]

Gene ID: 6752, updated on 13-Jan-2020

Summary

Official Symbol
SSTR2provided by HGNC
Official Full Name
somatostatin receptor 2provided by HGNC
Primary source
HGNC:HGNC:11331
See related
Ensembl:ENSG00000180616 MIM:182452
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 12.7), adrenal (RPKM 3.5) and 10 other tissues See more
Orthologs

Genomic context

See SSTR2 in Genome Data Viewer
Location:
17q25.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (73165010..73176633)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (71161160..71168094)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 11 Neighboring gene autophagy related 12 pseudogene 1 Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene family with sequence similarity 104 member A Neighboring gene component of oligomeric golgi complex 1 Neighboring gene chromosome 17 open reading frame 80 Neighboring gene cleavage and polyadenylation specific factor 4 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COG1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peristalsis IEA
Inferred from Electronic Annotation
more info
 
regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
 
response to starvation IEA
Inferred from Electronic Annotation
more info
 
somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
somatostatin receptor type 2
Names
SRIF-1
SS2R

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029371.1 RefSeqGene

    Range
    5001..11935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001050.3NP_001041.1  somatostatin receptor type 2

    See identical proteins and their annotated locations for NP_001041.1

    Status: REVIEWED

    Source sequence(s)
    AC097641, BC000256, BC019610
    Consensus CDS
    CCDS11691.1
    UniProtKB/Swiss-Prot
    P30874
    Related
    ENSP00000350198.2, ENST00000357585.4
    Conserved Domains (1) summary
    cd15971
    Location:44323
    7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    73165010..73176633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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