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COG1 component of oligomeric golgi complex 1 [ Homo sapiens (human) ]

Gene ID: 9382, updated on 8-Jul-2021

Summary

Official Symbol
COG1provided by HGNC
Official Full Name
component of oligomeric golgi complex 1provided by HGNC
Primary source
HGNC:HGNC:6545
See related
Ensembl:ENSG00000166685 MIM:606973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDLB; CDG2G
Summary
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 16.2), testis (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

See COG1 in Genome Data Viewer
Location:
17q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (73193055..73208507)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (71189194..71204646)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene somatostatin receptor 2 Neighboring gene family with sequence similarity 104 member A Neighboring gene chromosome 17 open reading frame 80 Neighboring gene cleavage and polyadenylation specific factor 4 like Neighboring gene Sharpr-MPRA regulatory region 4436 Neighboring gene CDC42 effector protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1381, DKFZp762L1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intra-Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Golgi transport complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 1
Names
COG complex subunit 1
conserved oligomeric Golgi complex protein 1
low density lipoprotein receptor defect B complementing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008971.1 RefSeqGene

    Range
    5022..20474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018714.3NP_061184.1  conserved oligomeric Golgi complex subunit 1

    See identical proteins and their annotated locations for NP_061184.1

    Status: REVIEWED

    Source sequence(s)
    AC097641, BC021985
    Consensus CDS
    CCDS11692.1
    UniProtKB/Swiss-Prot
    Q8WTW3
    Related
    ENSP00000299886.4, ENST00000299886.9
    Conserved Domains (1) summary
    pfam08700
    Location:1771
    Vps51; Vps51/Vps67

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    73193055..73208507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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