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Ccar1 cell division cycle and apoptosis regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 67500, updated on 24-Apr-2024

Summary

Official Symbol
Ccar1provided by MGI
Official Full Name
cell division cycle and apoptosis regulator 1provided by MGI
Primary source
MGI:MGI:1914750
See related
Ensembl:ENSMUSG00000020074 AllianceGenome:MGI:1914750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Carp1; 2610511G16Rik; 9430036H15Rik
Summary
Enables transcription coactivator activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 29.0), CNS E14 (RPKM 18.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ccar1 in Genome Data Viewer
Location:
10 B4; 10 32.47 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62579707..62628147, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62743928..62792368, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene STARR-seq mESC enhancer starr_26891 Neighboring gene STARR-seq mESC enhancer starr_26892 Neighboring gene microRNA 7215 Neighboring gene NHP2 ribonucleoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_26893 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene STARR-seq mESC enhancer starr_26894 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_26901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62328128-62328311 Neighboring gene STARR-seq mESC enhancer starr_26907 Neighboring gene predicted gene, 51805 Neighboring gene CRISPRi-validated Tet1 enhancer cluster Neighboring gene predicted gene, 26479

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90759

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cell division cycle and apoptosis regulator protein 1
Names
CARP-1
cell cycle and apoptosis regulatory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429504.1NP_001416433.1  cell division cycle and apoptosis regulator protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122539
  2. NM_001429505.1NP_001416434.1  cell division cycle and apoptosis regulator protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122539
  3. NM_001429506.1NP_001416435.1  cell division cycle and apoptosis regulator protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122539
  4. NM_001429507.1NP_001416436.1  cell division cycle and apoptosis regulator protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122539
  5. NM_001429508.1NP_001416437.1  cell division cycle and apoptosis regulator protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122539
  6. NM_001429509.1NP_001416438.1  cell division cycle and apoptosis regulator protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122539
  7. NM_001429510.1NP_001416439.1  cell division cycle and apoptosis regulator protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122539
  8. NM_001429511.1NP_001416440.1  cell division cycle and apoptosis regulator protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122539
  9. NM_026201.4NP_080477.1  cell division cycle and apoptosis regulator protein 1 isoform a

    See identical proteins and their annotated locations for NP_080477.1

    Status: VALIDATED

    Source sequence(s)
    AC122539
    Consensus CDS
    CCDS35922.1
    UniProtKB/Swiss-Prot
    Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
    Related
    ENSMUSP00000151895.2, ENSMUST00000219527.2
    Conserved Domains (5) summary
    smart00513
    Location:634667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:10341141
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:479598
    DBC1
    pfam14444
    Location:145201
    S1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62579707..62628147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513997.4XP_006514060.1  cell division cycle and apoptosis regulator protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q8CH18
    Conserved Domains (4) summary
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:9721079
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:476601
    DBC1
    pfam14444
    Location:145201
    S1-like
  2. XM_036155963.1XP_036011856.1  cell division cycle and apoptosis regulator protein 1 isoform X2

    Conserved Domains (4) summary
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:9721079
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:476601
    DBC1
    pfam14444
    Location:145201
    S1-like
  3. XM_006513996.4XP_006514059.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
    Conserved Domains (5) summary
    smart00513
    Location:634667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:10341141
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:479598
    DBC1
    pfam14444
    Location:145201
    S1-like
  4. XM_011243537.4XP_011241839.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
    Related
    ENSMUSP00000020268.6, ENSMUST00000020268.7
    Conserved Domains (5) summary
    smart00513
    Location:634667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:10341141
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:479598
    DBC1
    pfam14444
    Location:145201
    S1-like
  5. XM_006513994.5XP_006514057.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514057.1

    UniProtKB/Swiss-Prot
    Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
    Conserved Domains (5) summary
    smart00513
    Location:634667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:10341141
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:479598
    DBC1
    pfam14444
    Location:145201
    S1-like
  6. XM_006513995.4XP_006514058.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514058.1

    UniProtKB/Swiss-Prot
    Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
    Conserved Domains (5) summary
    smart00513
    Location:634667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:184303
    PRK10927; cell division protein FtsN
    TIGR04523
    Location:10341141
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14443
    Location:479598
    DBC1
    pfam14444
    Location:145201
    S1-like