Format

Send to:

Choose Destination

CCAR1 cell division cycle and apoptosis regulator 1 [ Homo sapiens (human) ]

Gene ID: 55749, updated on 23-Nov-2021

Summary

Official Symbol
CCAR1provided by HGNC
Official Full Name
cell division cycle and apoptosis regulator 1provided by HGNC
Primary source
HGNC:HGNC:24236
See related
Ensembl:ENSG00000060339 MIM:612569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 17.5), appendix (RPKM 15.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CCAR1 in Genome Data Viewer
Location:
10q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (68721239..68792377)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70480996..70552134)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene COX20 pseudogene 1 Neighboring gene RPS3A pseudogene 37 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene RNA, U6 small nuclear 697, pseudogene Neighboring gene storkhead box 1 Neighboring gene RNA, U6 small nuclear 571, pseudogene Neighboring gene DExD-box helicase 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cell division cycle and apoptosis regulator 1 (CCAR1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of cell division cycle and apoptosis regulator 1 (CCAR1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44628

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell division cycle and apoptosis regulator protein 1
Names
cell cycle and apoptosis regulatory protein 1
death inducer with SAP domain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282959.2NP_001269888.1  cell division cycle and apoptosis regulator protein 1 isoform b

    See identical proteins and their annotated locations for NP_001269888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK298004, AK299307, AY249140, BC132725, BU617955, DB636717
    Consensus CDS
    CCDS60547.1
    UniProtKB/Swiss-Prot
    Q8IX12
    Related
    ENSP00000445254.1, ENST00000543719.5
    Conserved Domains (5) summary
    smart00513
    Location:622655
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:266298
    PHA03356; tegument protein UL11; Provisional
    pfam14443
    Location:467586
    DBC1; DBC1
    pfam14444
    Location:137189
    S1-like; S1-like
    cl23720
    Location:10211100
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001282960.2NP_001269889.1  cell division cycle and apoptosis regulator protein 1 isoform b

    See identical proteins and their annotated locations for NP_001269889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK299307, AY249140, BC132725, BU617955, DA511293, DB636717
    Consensus CDS
    CCDS60547.1
    UniProtKB/Swiss-Prot
    Q8IX12
    Related
    ENSP00000439252.1, ENST00000539539.5
    Conserved Domains (5) summary
    smart00513
    Location:622655
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:266298
    PHA03356; tegument protein UL11; Provisional
    pfam14443
    Location:467586
    DBC1; DBC1
    pfam14444
    Location:137189
    S1-like; S1-like
    cl23720
    Location:10211100
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. NM_018237.4NP_060707.2  cell division cycle and apoptosis regulator protein 1 isoform a

    See identical proteins and their annotated locations for NP_060707.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AY249140, BC132725, BU617955, DA511293, DB636717
    Consensus CDS
    CCDS7282.1
    UniProtKB/Swiss-Prot
    Q8IX12
    Related
    ENSP00000265872.6, ENST00000265872.11
    Conserved Domains (5) summary
    smart00513
    Location:637670
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:281313
    PHA03356; tegument protein UL11; Provisional
    pfam14443
    Location:482601
    DBC1; DBC1
    pfam14444
    Location:152204
    S1-like; S1-like
    cl23720
    Location:10361115
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RNA

  1. NR_104262.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY249140, BC144118, BU617955, DA511293, DB636717
    Related
    ENST00000630771.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    68721239..68792377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center