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BPI bactericidal permeability increasing protein [ Homo sapiens (human) ]

Gene ID: 671, updated on 1-Jun-2020

Summary

Official Symbol
BPIprovided by HGNC
Official Full Name
bactericidal permeability increasing proteinprovided by HGNC
Primary source
HGNC:HGNC:1095
See related
Ensembl:ENSG00000101425 MIM:109195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
rBPI; BPIFD1
Summary
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward bone marrow (RPKM 549.1) See more
Orthologs

Genomic context

See BPI in Genome Data Viewer
Location:
20q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38304156..38337505)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36932552..36965907)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transglutaminase 2 Neighboring gene uncharacterized LOC107987281 Neighboring gene KIAA1755 Neighboring gene uncharacterized LOC149684 Neighboring gene lipopolysaccharide binding protein Neighboring gene small nucleolar RNA, H/ACA box 71B Neighboring gene small nucleolar RNA host gene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-8 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bactericidal permeability-increasing protein
Names
BPI fold containing family D, member 1
CAP 57
recombinant BPI holoprotein, rBPI

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047016.1 RefSeqGene

    Range
    5007..38356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001725.3NP_001716.3  bactericidal permeability-increasing protein precursor

    Status: REVIEWED

    Source sequence(s)
    AL359555, AL391095, AL499625
    Consensus CDS
    CCDS13303.1
    Related
    ENSP00000494528.2, ENST00000642449.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38304156..38337505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451972.1XP_024307740.1  bactericidal permeability-increasing protein isoform X1

    Related
    ENSP00000409833.2, ENST00000417318.3
    Conserved Domains (2) summary
    pfam02886
    Location:51251
    LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain
    cl00188
    Location:166
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
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