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Bpi bactericidal permeablility increasing protein [ Mus musculus (house mouse) ]

Gene ID: 329547, updated on 18-Sep-2024

Summary

Official Symbol
Bpiprovided by MGI
Official Full Name
bactericidal permeablility increasing proteinprovided by MGI
Primary source
MGI:MGI:3045315
See related
Ensembl:ENSMUSG00000052922 AllianceGenome:MGI:3045315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bpifd1; 9230105K17Rik
Summary
Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of macrophage activation; and response to bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPI (bactericidal permeability increasing protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 29.4) and testis adult (RPKM 24.9) See more
Orthologs
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Genomic context

See Bpi in Genome Data Viewer
Location:
2 H1; 2 78.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158099983..158126453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158258063..158284533)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630003M21 gene Neighboring gene RIKEN cDNA 1700060C20 gene Neighboring gene microRNA 7685 Neighboring gene predicted gene, 34571 Neighboring gene lipopolysaccharide binding protein Neighboring gene small nucleolar RNA host gene 17 Neighboring gene predicted gene, 24411

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bactericidal permeability-increasing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356542.1NP_001343471.1  bactericidal permeability-increasing protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AY648037
    Consensus CDS
    CCDS89574.1
    UniProtKB/Swiss-Prot
    A2AC63, Q5I5I4, Q67E05, Q8BSF3
    Related
    ENSMUSP00000105125.2, ENSMUST00000109499.8
    Conserved Domains (2) summary
    smart00328
    Location:36259
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:244482
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
  2. NM_177850.3NP_808518.1  bactericidal permeability-increasing protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_808518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033770
    Consensus CDS
    CCDS16987.1
    UniProtKB/Swiss-Prot
    Q67E05
    Related
    ENSMUSP00000067837.3, ENSMUST00000065039.3
    Conserved Domains (2) summary
    smart00328
    Location:36259
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:244485
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158099983..158126453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319055.1XP_017174544.1  bactericidal permeability-increasing protein isoform X1

    Related
    ENSMUSP00000105126.2, ENSMUST00000109500.8
    Conserved Domains (2) summary
    smart00328
    Location:86309
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:294531
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
  2. XM_017319056.2XP_017174545.1  bactericidal permeability-increasing protein isoform X2

    Conserved Domains (2) summary
    smart00328
    Location:34211
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:196434
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...