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BNIP3 BCL2 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 664, updated on 1-Mar-2024

Summary

Official Symbol
BNIP3provided by HGNC
Official Full Name
BCL2 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:1084
See related
Ensembl:ENSG00000176171 MIM:603293; AllianceGenome:HGNC:1084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP3; HABON
Summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more
Orthologs
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Genomic context

See BNIP3 in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131967684..131981923, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (132907935..132922186, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781188..133795427, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2948 Neighboring gene Sharpr-MPRA regulatory region 4393 Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:133747865-133749064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133758459-133759288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133761987-133762488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133785771-133786641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133794606-133795530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene uncharacterized LOC124902525 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) in human B cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cobalt ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in granzyme-mediated programmed cell death signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial outer membrane permeabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial outer membrane permeabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxygen-glucose deprivation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Names
BCL2/adenovirus E1B 19kDa interacting protein 3
BCL2/adenovirus E1B interacting protein 3
Hypoxia-Activated BNIP3 Overlapping Non-coding RNA
nineteen kD interacting protein-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004052.4NP_004043.4  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

    Status: REVIEWED

    Source sequence(s)
    AL162274, AL732395
    Consensus CDS
    CCDS7663.3
    UniProtKB/Swiss-Prot
    O14620, Q12983, Q96GP0
    UniProtKB/TrEMBL
    Q53HF4
    Related
    ENSP00000357625.6, ENST00000368636.9
    Conserved Domains (1) summary
    pfam06553
    Location:9192
    BNIP3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    131967684..131981923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    132907935..132922186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)