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BNIP3 BCL2 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 664, updated on 9-May-2021

Summary

Official Symbol
BNIP3provided by HGNC
Official Full Name
BCL2 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:1084
See related
Ensembl:ENSG00000176171 MIM:603293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP3
Summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more
Orthologs
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Genomic context

See BNIP3 in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (131967684..131981923, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781187..133795517, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene uncharacterized LOC105378567 Neighboring gene dihydropyrimidinase like 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) in human B cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cobalt ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in granzyme-mediated programmed cell death signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial outer membrane permeabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial outer membrane permeabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxygen-glucose deprivation IEA
Inferred from Electronic Annotation
more info
 
involved_in toxin transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Names
BCL2/adenovirus E1B 19kDa interacting protein 3
BCL2/adenovirus E1B interacting protein 3
nineteen kD interacting protein-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004052.4NP_004043.4  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

    Status: REVIEWED

    Source sequence(s)
    AL162274, AL732395
    Consensus CDS
    CCDS7663.2
    Related
    ENSP00000357625.5, ENST00000368636.8
    Conserved Domains (1) summary
    pfam06553
    Location:9192
    BNIP3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    131967684..131981923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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