U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC2A11 solute carrier family 2 member 11 [ Homo sapiens (human) ]

Gene ID: 66035, updated on 22-Sep-2022

Summary

Official Symbol
SLC2A11provided by HGNC
Official Full Name
solute carrier family 2 member 11provided by HGNC
Primary source
HGNC:HGNC:14239
See related
Ensembl:ENSG00000133460 MIM:610367; AllianceGenome:HGNC:14239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT10; GLUT11
Summary
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in kidney (RPKM 6.0), brain (RPKM 3.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC2A11 in Genome Data Viewer
Location:
22q11.23
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23856934..23886312)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24301547..24330924)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24199121..24228499)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene skeletal muscle cis-regulatory module in DERL3 and SLC2A11 intergenic region Neighboring gene derlin 3 Neighboring gene RNA, 7SL, cytoplasmic 268, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10281 Neighboring gene MIF antisense RNA 1 Neighboring gene macrophage migration inhibitory factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MIF

Homology

Clone Names

  • FLJ30961, MGC118830, MGC118833

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in fructose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 11
Names
facilitative glucose transporter GLUT11
glucose transporter protein 10
glucose transporter protein 11
glucose transporter type 10
glucose transporter type 11
glucose transporter-like protein XI
solute carrier family 2 (facilitated glucose transporter), member 11

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024938.4NP_001020109.1  solute carrier family 2, facilitated glucose transporter member 11 isoform c

    See identical proteins and their annotated locations for NP_001020109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as SLC2A11-a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (c, also known as GLUT11-S) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK075467, AP000350, BC018967
    Consensus CDS
    CCDS46673.1
    UniProtKB/Swiss-Prot
    Q8WYM4, Q9BYW1
    UniProtKB/TrEMBL
    Q6PJ99
    Related
    ENSP00000342542.5, ENST00000345044.10
    Conserved Domains (1) summary
    cd17432
    Location:16467
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  2. NM_001024939.4NP_001020110.1  solute carrier family 2, facilitated glucose transporter member 11 isoform b

    See identical proteins and their annotated locations for NP_001020110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as SLC2A11-c) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK092466, AP000350, DC303452
    Consensus CDS
    CCDS33616.1
    UniProtKB/Swiss-Prot
    Q9BYW1
    Related
    ENSP00000326748.8, ENST00000316185.9
    Conserved Domains (2) summary
    cd06174
    Location:64460
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18471
    Sugar_tr; Sugar (and other) transporter
  3. NM_001282864.2NP_001269793.1  solute carrier family 2, facilitated glucose transporter member 11 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The encoded isoform (d) is longer and has a distinct C- terminus, compared to isoform a.
    Source sequence(s)
    AK092466, AK300196, AP000350
    Consensus CDS
    CCDS74828.1
    UniProtKB/TrEMBL
    A0A087X018, B7Z6F0
    Related
    ENSP00000483038.1, ENST00000611880.4
    Conserved Domains (2) summary
    cd06174
    Location:68217
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:22428
    Sugar_tr; Sugar (and other) transporter
  4. NM_030807.5NP_110434.3  solute carrier family 2, facilitated glucose transporter member 11 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as SLC2A11-b) encodes isoform a (also known as GLUT11-L).
    Source sequence(s)
    AJ271290, AK092466, AK314502, AP000350
    Consensus CDS
    CCDS13818.1
    UniProtKB/Swiss-Prot
    Q9BYW1
    Related
    ENSP00000381399.2, ENST00000398356.6
    Conserved Domains (2) summary
    cd06174
    Location:68464
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:22475
    Sugar_tr; Sugar (and other) transporter

RNA

  1. NR_104247.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two internal exons and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK092466, AP000350, BC100810, DA084206
  2. NR_104248.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as SLC2A11-s) lacks multiple 3' exons and its 3' terminal exon extends past a splice site used in variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, results in an open reading frame that lacks an in-frame stop codon.
    Source sequence(s)
    BC063525, DA084206
    Related
    ENST00000467660.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23856934..23886312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    93296..122674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24301547..24330924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)