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MIF macrophage migration inhibitory factor [ Homo sapiens (human) ]

Gene ID: 4282, updated on 19-Aug-2018

Summary

Official Symbol
MIFprovided by HGNC
Official Full Name
macrophage migration inhibitory factorprovided by HGNC
Primary source
HGNC:HGNC:7097
See related
Ensembl:ENSG00000240972 MIM:153620; Vega:OTTHUMG00000150773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIF; GLIF; MMIF
Summary
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues See more
Orthologs

Genomic context

See MIF in Genome Data Viewer
Location:
22q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (23894378..23895222)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24236565..24237409)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene skeletal muscle cis-regulatory module in DERL3 and SLC2A11 intergenic region Neighboring gene solute carrier family 2 member 11 Neighboring gene RNA, 7SL, cytoplasmic 268, pseudogene Neighboring gene MIF antisense RNA 1 Neighboring gene uncharacterized LOC107985558 Neighboring gene kelch like family member 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Rheumatoid arthritis, systemic juvenile
MedGen: C1858558 OMIM: 604302 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
Tat tat HIV-1 Tat upregulates the expression of macrophage migration inhibitory factor gene (glycosylation-inhibiting factor, MIF) in mammary epithelial cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL-6, IL-8, MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Phenylalanine metabolism, organism-specific biosystem (from KEGG)
    Phenylalanine metabolism, organism-specific biosystem
    Phenylalanine metabolism
  • Phenylalanine metabolism, conserved biosystem (from KEGG)
    Phenylalanine metabolism, conserved biosystem
    Phenylalanine metabolism
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Tyrosine metabolism, organism-specific biosystem (from KEGG)
    Tyrosine metabolism, organism-specific biosystem
    Tyrosine metabolism
  • Tyrosine metabolism, conserved biosystem (from KEGG)
    Tyrosine metabolism, conserved biosystem
    Tyrosine metabolism

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
dopachrome isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phenylpyruvate tautomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell aging IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mature B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myeloid leukocyte cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of prostaglandin secretion involved in immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein homotrimerization IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
macrophage migration inhibitory factor
Names
L-dopachrome isomerase
L-dopachrome tautomerase
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
phenylpyruvate tautomerase
NP_002406.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012099.1 RefSeqGene

    Range
    5001..5845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002415.1NP_002406.1  macrophage migration inhibitory factor

    See identical proteins and their annotated locations for NP_002406.1

    Status: REVIEWED

    Source sequence(s)
    L19686
    Consensus CDS
    CCDS13819.1
    UniProtKB/Swiss-Prot
    P14174
    UniProtKB/TrEMBL
    I4AY87
    Related
    ENSP00000215754.7, OTTHUMP00000198465, ENST00000215754.7, OTTHUMT00000320009
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    23894378..23895222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    130740..131584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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