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MIF macrophage migration inhibitory factor [ Homo sapiens (human) ]

Gene ID: 4282, updated on 6-May-2021

Summary

Official Symbol
MIFprovided by HGNC
Official Full Name
macrophage migration inhibitory factorprovided by HGNC
Primary source
HGNC:HGNC:7097
See related
Ensembl:ENSG00000240972 MIM:153620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIF; GLIF; MMIF
Summary
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues See more
Orthologs
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Genomic context

See MIF in Genome Data Viewer
Location:
22q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (23894383..23895223)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24236570..24237410)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 11 Neighboring gene RNA, 7SL, cytoplasmic 268, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10281 Neighboring gene MIF antisense RNA 1 Neighboring gene uncharacterized LOC107985558 Neighboring gene kelch like family member 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
GeneReviews: Not available
Rheumatoid arthritis, systemic juvenile
MedGen: C1858558 OMIM: 604302 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
Tat tat HIV-1 Tat upregulates the expression of macrophage migration inhibitory factor gene (glycosylation-inhibiting factor, MIF) in mammary epithelial cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL-6, IL-8, MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables dopachrome isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phenylpyruvate tautomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in leukocyte migration TAS
Traceable Author Statement
more info
 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil degranulation TAS
Traceable Author Statement
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homotrimerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
macrophage migration inhibitory factor
Names
L-dopachrome isomerase
L-dopachrome tautomerase
epididymis secretory sperm binding protein
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
phenylpyruvate tautomerase
NP_002406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012099.1 RefSeqGene

    Range
    5006..5846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002415.2NP_002406.1  macrophage migration inhibitory factor

    See identical proteins and their annotated locations for NP_002406.1

    Status: REVIEWED

    Source sequence(s)
    AP000350
    Consensus CDS
    CCDS13819.1
    UniProtKB/Swiss-Prot
    P14174
    UniProtKB/TrEMBL
    I4AY87
    Related
    ENSP00000215754.7, ENST00000215754.8
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    23894383..23895223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    130745..131585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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