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SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [ Homo sapiens (human) ]

Gene ID: 6599, updated on 17-Nov-2018

Summary

Official Symbol
SMARCC1provided by HGNC
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1provided by HGNC
Primary source
HGNC:HGNC:11104
See related
Ensembl:ENSG00000173473 MIM:601732; Vega:OTTHUMG00000133519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rsc8; SRG3; SWI3; BAF155; CRACC1
Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.4), endometrium (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See SMARCC1 in Genome Data Viewer
Location:
3p21.31
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (47585888..47781915, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47627378..47823405, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 870, pseudogene Neighboring gene chondroitin sulfate proteoglycan 5 Neighboring gene HIG1 domain family member 2A, mitochondrial pseudogene Neighboring gene small nucleolar RNA, C/D box 146 Neighboring gene DExH-box helicase 30 Neighboring gene microRNA 1226 Neighboring gene microtubule associated protein 4 Neighboring gene VPS26B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces phosphorylation of BRG1 and BAF155 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ATP-dependent chromatin remodeling HDA PubMed 
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
nucleosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
prostate gland development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
XY body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
npBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromatin HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex HDA PubMed 

General protein information

Preferred Names
SWI/SNF complex subunit SMARCC1
Names
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
chromatin remodeling complex BAF155 subunit
mammalian chromatin remodeling complex BRG1-associated factor 155

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003074.3NP_003065.3  SWI/SNF complex subunit SMARCC1

    See identical proteins and their annotated locations for NP_003065.3

    Status: VALIDATED

    Source sequence(s)
    BC012101, BC040242, BC050564
    Consensus CDS
    CCDS2758.1
    UniProtKB/Swiss-Prot
    Q92922
    UniProtKB/TrEMBL
    Q58EY4
    Related
    ENSP00000254480.5, OTTHUMP00000164798, ENST00000254480.9, OTTHUMT00000257491
    Conserved Domains (5) summary
    COG5259
    Location:444710
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:452537
    SWIRM; SWIRM domain
    pfam16495
    Location:883954
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:32445
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:706770
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    47585888..47781915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534034.1XP_011532336.1  SWI/SNF complex subunit SMARCC1 isoform X1

    Conserved Domains (5) summary
    COG5259
    Location:335601
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:343428
    SWIRM; SWIRM domain
    pfam16495
    Location:774845
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:1336
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:597661
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

RNA

  1. XR_001740239.1 RNA Sequence

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